Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case
Abstract Background To describe a 14-year-old male with probable ocular sarcoidosis and bilateral peripapillary choroidal neovascularization (PCNV). Case presentation We report a case of a 14-year-old boy with a 2-month history of floaters and gradual vision loss in both eyes. Examination revealed b...
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BMC
2025-07-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-04266-7 |
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| author | Yuan Zong Keyan Wang Ting Zhang Gezhi Xu |
| author_facet | Yuan Zong Keyan Wang Ting Zhang Gezhi Xu |
| author_sort | Yuan Zong |
| collection | DOAJ |
| description | Abstract Background To describe a 14-year-old male with probable ocular sarcoidosis and bilateral peripapillary choroidal neovascularization (PCNV). Case presentation We report a case of a 14-year-old boy with a 2-month history of floaters and gradual vision loss in both eyes. Examination revealed bilateral granulomatous uveitis with peripapillary subretinal lesions. The serum angiotensin-converting enzyme was elevated. Positron emission tomography demonstrated increased metabolic activity in the nasopharynx and small intestine, consistent with diagnosis of sarcoidosis. Despite resolution of vitreous cells and retinal vasculitis, the PCNV progressed slowly in the left eye, which was controlled with combined treatment of immunomodulatory regiment and multiple intravitreal anti-vascular endothelial growth factor injections over a prolonged period. Conclusions This case highlights the need for a multidisciplinary approach and long-term follow-up in pediatric ocular sarcoidosis with PCNV. |
| format | Article |
| id | doaj-art-03dd2f9231fc4d22bb8cd5db46ccd5f2 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-03dd2f9231fc4d22bb8cd5db46ccd5f22025-08-20T03:42:35ZengBMCBMC Ophthalmology1471-24152025-07-012511510.1186/s12886-025-04266-7Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up caseYuan Zong0Keyan Wang1Ting Zhang2Gezhi Xu3Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan UniversityAbstract Background To describe a 14-year-old male with probable ocular sarcoidosis and bilateral peripapillary choroidal neovascularization (PCNV). Case presentation We report a case of a 14-year-old boy with a 2-month history of floaters and gradual vision loss in both eyes. Examination revealed bilateral granulomatous uveitis with peripapillary subretinal lesions. The serum angiotensin-converting enzyme was elevated. Positron emission tomography demonstrated increased metabolic activity in the nasopharynx and small intestine, consistent with diagnosis of sarcoidosis. Despite resolution of vitreous cells and retinal vasculitis, the PCNV progressed slowly in the left eye, which was controlled with combined treatment of immunomodulatory regiment and multiple intravitreal anti-vascular endothelial growth factor injections over a prolonged period. Conclusions This case highlights the need for a multidisciplinary approach and long-term follow-up in pediatric ocular sarcoidosis with PCNV.https://doi.org/10.1186/s12886-025-04266-7SarcoidosisChoroidal neovascularizationUveitisPediatricAnti-vascular endothelial growth factorImmunosuppressive agents |
| spellingShingle | Yuan Zong Keyan Wang Ting Zhang Gezhi Xu Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case BMC Ophthalmology Sarcoidosis Choroidal neovascularization Uveitis Pediatric Anti-vascular endothelial growth factor Immunosuppressive agents |
| title | Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case |
| title_full | Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case |
| title_fullStr | Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case |
| title_full_unstemmed | Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case |
| title_short | Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case |
| title_sort | pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis a long term follow up case |
| topic | Sarcoidosis Choroidal neovascularization Uveitis Pediatric Anti-vascular endothelial growth factor Immunosuppressive agents |
| url | https://doi.org/10.1186/s12886-025-04266-7 |
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