Protective Effect of Laminaria japonica with Probiotics on Murine Colitis
Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Most IBD treatments are unsatisfactory; therefore, various dietary supplements have emerged as promising interventions. Laminaria japonica (LJ) is an edible seaweed used to regulate diges...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/417814 |
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| author | Seok-Jae Ko Youngmin Bu Jinhyun Bae Yu-mi Bang Jinsung Kim Hyejung Lee Lee Beom-Joon Yoo Hye Hyun Jae-Woo Park |
| author_facet | Seok-Jae Ko Youngmin Bu Jinhyun Bae Yu-mi Bang Jinsung Kim Hyejung Lee Lee Beom-Joon Yoo Hye Hyun Jae-Woo Park |
| author_sort | Seok-Jae Ko |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Most IBD treatments are unsatisfactory; therefore, various dietary supplements have emerged as promising interventions. Laminaria japonica (LJ) is an edible seaweed used to regulate digestive symptoms. Probiotics have been reported to improve digestive problems and their simultaneous administration with seaweeds has been shown to produce synergistic therapeutic effects. Here, we investigated the effect of LJ combination with probiotics on dextran sodium sulfate-induced colitis model in mice. Aqueous LJ extracts (LJE) at doses from 100 to 300 mg/kg and probiotics at a dose of 300 mg/kg were orally administered for 7 days. Body weight, colon length, histological score, macroscopic damage, and the levels of cytokines IFN-γ, IL-1β, IL-6, IL-10, IL-12 (P40), IL-12 (P70), IL-17, and TNF-α were assessed. LJE alone caused a significant improvement of colitis signs such as colon length, histological score, and IL-1β and IL-6 production. LJE and probiotics demonstrated a synergistic effect by the histological score and levels of IL-1β, IL-6, and IL-12 (P40) but not IFN-γ, IL-10, and IL-12 (P70). In conclusion, LJE was effective in inducing protection against colitis in mice and acted synergistically with probiotics. |
| format | Article |
| id | doaj-art-03dd2bcaf5624d438adf720e46a8a4f3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-03dd2bcaf5624d438adf720e46a8a4f32025-02-03T05:48:07ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/417814417814Protective Effect of Laminaria japonica with Probiotics on Murine ColitisSeok-Jae Ko0Youngmin Bu1Jinhyun Bae2Yu-mi Bang3Jinsung Kim4Hyejung Lee5Lee Beom-Joon6Yoo Hye Hyun7Jae-Woo Park8College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaAcupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaDepartment of Pharmacy, College of Pharmacy, Hanyang University, Ansan 426-791, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaInflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Most IBD treatments are unsatisfactory; therefore, various dietary supplements have emerged as promising interventions. Laminaria japonica (LJ) is an edible seaweed used to regulate digestive symptoms. Probiotics have been reported to improve digestive problems and their simultaneous administration with seaweeds has been shown to produce synergistic therapeutic effects. Here, we investigated the effect of LJ combination with probiotics on dextran sodium sulfate-induced colitis model in mice. Aqueous LJ extracts (LJE) at doses from 100 to 300 mg/kg and probiotics at a dose of 300 mg/kg were orally administered for 7 days. Body weight, colon length, histological score, macroscopic damage, and the levels of cytokines IFN-γ, IL-1β, IL-6, IL-10, IL-12 (P40), IL-12 (P70), IL-17, and TNF-α were assessed. LJE alone caused a significant improvement of colitis signs such as colon length, histological score, and IL-1β and IL-6 production. LJE and probiotics demonstrated a synergistic effect by the histological score and levels of IL-1β, IL-6, and IL-12 (P40) but not IFN-γ, IL-10, and IL-12 (P70). In conclusion, LJE was effective in inducing protection against colitis in mice and acted synergistically with probiotics.http://dx.doi.org/10.1155/2014/417814 |
| spellingShingle | Seok-Jae Ko Youngmin Bu Jinhyun Bae Yu-mi Bang Jinsung Kim Hyejung Lee Lee Beom-Joon Yoo Hye Hyun Jae-Woo Park Protective Effect of Laminaria japonica with Probiotics on Murine Colitis Mediators of Inflammation |
| title | Protective Effect of Laminaria japonica with Probiotics on Murine Colitis |
| title_full | Protective Effect of Laminaria japonica with Probiotics on Murine Colitis |
| title_fullStr | Protective Effect of Laminaria japonica with Probiotics on Murine Colitis |
| title_full_unstemmed | Protective Effect of Laminaria japonica with Probiotics on Murine Colitis |
| title_short | Protective Effect of Laminaria japonica with Probiotics on Murine Colitis |
| title_sort | protective effect of laminaria japonica with probiotics on murine colitis |
| url | http://dx.doi.org/10.1155/2014/417814 |
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