The Effect of Paracetamol on The Development of Chicken Embryos
Paracetamol (N-Acetylaminophenol) is the most widely used over-the-counter drug in the world. Although considered safe for pregnant mothers, there is a concern regarding the teratogenic effect of paracetamol. This study aims to observe the teratogenic effect of paracetamol developing embryos. Using...
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| Format: | Article |
| Language: | English |
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State Islamic University Sunan Kalijaga
2024-11-01
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| Series: | Biology, Medicine & Natural Product Chemistry |
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| Online Access: | https://sciencebiology.org/index.php/BIOMEDICH/article/view/607 |
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| author | Hendry Tri Sakti Surya Gunawan Saragih Alfian Primahesa Shintia Oktaviana Agnessia Asian Budi Setyo Alifia Anisya Hayu Swari Allimi Laili Mufli Zusrina Ruth Liananda Citra Dolok Saribu Ardaning Nuriliani Nur Indah Septriani |
| author_facet | Hendry Tri Sakti Surya Gunawan Saragih Alfian Primahesa Shintia Oktaviana Agnessia Asian Budi Setyo Alifia Anisya Hayu Swari Allimi Laili Mufli Zusrina Ruth Liananda Citra Dolok Saribu Ardaning Nuriliani Nur Indah Septriani |
| author_sort | Hendry Tri Sakti Surya Gunawan Saragih |
| collection | DOAJ |
| description | Paracetamol (N-Acetylaminophenol) is the most widely used over-the-counter drug in the world. Although considered safe for pregnant mothers, there is a concern regarding the teratogenic effect of paracetamol. This study aims to observe the teratogenic effect of paracetamol developing embryos. Using chicken embryos, the embryos were incubated for 48 hours and then injected with paracetamol in 3 concentrations, namely 10 ppm, 15 ppm, and 20 ppm. The control group and treatment group consisted of 3 replicates of fertile embryos. Then, the embryos were incubated again for 48 hours in the incubator. Data analysis was carried out qualitatively by observing any developmental alterations. Results showed that paracetamol caused enlargement of the head and heart edema. Exposure to paracetamol at concentrations of 15 ppm and 20 ppm affects the morphology of chicken embryos, especially the formation of the head and disrupts the process of angiogenesis and normal heart formation, causing bleeding and edema at higher concentrations. |
| format | Article |
| id | doaj-art-03d9960f4d834514bb41c7148ca219a7 |
| institution | OA Journals |
| issn | 2089-6514 2540-9328 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | State Islamic University Sunan Kalijaga |
| record_format | Article |
| series | Biology, Medicine & Natural Product Chemistry |
| spelling | doaj-art-03d9960f4d834514bb41c7148ca219a72025-08-20T02:04:13ZengState Islamic University Sunan KalijagaBiology, Medicine & Natural Product Chemistry2089-65142540-93282024-11-0113255956410.14421/biomedich.2024.132.559-564309The Effect of Paracetamol on The Development of Chicken EmbryosHendry Tri Sakti Surya Gunawan Saragih0Alfian Primahesa1Shintia Oktaviana2Agnessia Asian Budi Setyo3Alifia Anisya4Hayu Swari Allimi5Laili Mufli Zusrina6Ruth Liananda Citra Dolok Saribu7Ardaning Nuriliani8Nur Indah Septriani9Faculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaFaculty of Biology, Universitas Gadjah MadaParacetamol (N-Acetylaminophenol) is the most widely used over-the-counter drug in the world. Although considered safe for pregnant mothers, there is a concern regarding the teratogenic effect of paracetamol. This study aims to observe the teratogenic effect of paracetamol developing embryos. Using chicken embryos, the embryos were incubated for 48 hours and then injected with paracetamol in 3 concentrations, namely 10 ppm, 15 ppm, and 20 ppm. The control group and treatment group consisted of 3 replicates of fertile embryos. Then, the embryos were incubated again for 48 hours in the incubator. Data analysis was carried out qualitatively by observing any developmental alterations. Results showed that paracetamol caused enlargement of the head and heart edema. Exposure to paracetamol at concentrations of 15 ppm and 20 ppm affects the morphology of chicken embryos, especially the formation of the head and disrupts the process of angiogenesis and normal heart formation, causing bleeding and edema at higher concentrations.https://sciencebiology.org/index.php/BIOMEDICH/article/view/607abnormalitychicken embryodevelopmentparacetamol |
| spellingShingle | Hendry Tri Sakti Surya Gunawan Saragih Alfian Primahesa Shintia Oktaviana Agnessia Asian Budi Setyo Alifia Anisya Hayu Swari Allimi Laili Mufli Zusrina Ruth Liananda Citra Dolok Saribu Ardaning Nuriliani Nur Indah Septriani The Effect of Paracetamol on The Development of Chicken Embryos Biology, Medicine & Natural Product Chemistry abnormality chicken embryo development paracetamol |
| title | The Effect of Paracetamol on The Development of Chicken Embryos |
| title_full | The Effect of Paracetamol on The Development of Chicken Embryos |
| title_fullStr | The Effect of Paracetamol on The Development of Chicken Embryos |
| title_full_unstemmed | The Effect of Paracetamol on The Development of Chicken Embryos |
| title_short | The Effect of Paracetamol on The Development of Chicken Embryos |
| title_sort | effect of paracetamol on the development of chicken embryos |
| topic | abnormality chicken embryo development paracetamol |
| url | https://sciencebiology.org/index.php/BIOMEDICH/article/view/607 |
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