Recent advances in calcium peroxide nanomedicines for breast cancer treatment
Abstract As a typical solid tumor, breast cancer is characterized by a tumor microenvironment featuring hypoxia, acidosis, and highly reductive conditions. These factors contribute to treatment resistance (e.g., chemoresistance) through various mechanisms, thereby diminishing therapeutic efficacy. C...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03329-x |
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| _version_ | 1849331625377136640 |
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| author | Sirui Hang Liu Xu Ruixue Ma Huiqin Xu Xiaojuan Zhang Chuanchuan He |
| author_facet | Sirui Hang Liu Xu Ruixue Ma Huiqin Xu Xiaojuan Zhang Chuanchuan He |
| author_sort | Sirui Hang |
| collection | DOAJ |
| description | Abstract As a typical solid tumor, breast cancer is characterized by a tumor microenvironment featuring hypoxia, acidosis, and highly reductive conditions. These factors contribute to treatment resistance (e.g., chemoresistance) through various mechanisms, thereby diminishing therapeutic efficacy. Calcium peroxide (CaO2) can generate multiple bioactive molecules (metal ions, H2O2, O2, and OH−) in acidic or neutral environment, making it a promising biomaterial for cancer therapy. Recently, breast cancer has been extensively targeted using CaO2 nanoparticles in both cellular and murine models. In this review, we first provide a summary of strategies employing CaO2 nanomedicine-based breast cancer therapies, then discuss the obstacles and development directions of CaO2 application in breast cancer therapy. |
| format | Article |
| id | doaj-art-03cfadcab5ca4146b042f9e8ddad832e |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-03cfadcab5ca4146b042f9e8ddad832e2025-08-20T03:46:28ZengSpringerDiscover Oncology2730-60112025-08-0116111110.1007/s12672-025-03329-xRecent advances in calcium peroxide nanomedicines for breast cancer treatmentSirui Hang0Liu Xu1Ruixue Ma2Huiqin Xu3Xiaojuan Zhang4Chuanchuan He5Zhejiang Chinese Medical UniversityAffiliated Hospital of Jiaxing UniversityDepartment of Pharmaceutics, College of Medicine, Jiaxing UniversityJiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing UniversityDepartment of Pharmaceutics, College of Medicine, Jiaxing UniversityJiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing UniversityAbstract As a typical solid tumor, breast cancer is characterized by a tumor microenvironment featuring hypoxia, acidosis, and highly reductive conditions. These factors contribute to treatment resistance (e.g., chemoresistance) through various mechanisms, thereby diminishing therapeutic efficacy. Calcium peroxide (CaO2) can generate multiple bioactive molecules (metal ions, H2O2, O2, and OH−) in acidic or neutral environment, making it a promising biomaterial for cancer therapy. Recently, breast cancer has been extensively targeted using CaO2 nanoparticles in both cellular and murine models. In this review, we first provide a summary of strategies employing CaO2 nanomedicine-based breast cancer therapies, then discuss the obstacles and development directions of CaO2 application in breast cancer therapy.https://doi.org/10.1007/s12672-025-03329-xCaO2Breast cancerROSHypoxia |
| spellingShingle | Sirui Hang Liu Xu Ruixue Ma Huiqin Xu Xiaojuan Zhang Chuanchuan He Recent advances in calcium peroxide nanomedicines for breast cancer treatment Discover Oncology CaO2 Breast cancer ROS Hypoxia |
| title | Recent advances in calcium peroxide nanomedicines for breast cancer treatment |
| title_full | Recent advances in calcium peroxide nanomedicines for breast cancer treatment |
| title_fullStr | Recent advances in calcium peroxide nanomedicines for breast cancer treatment |
| title_full_unstemmed | Recent advances in calcium peroxide nanomedicines for breast cancer treatment |
| title_short | Recent advances in calcium peroxide nanomedicines for breast cancer treatment |
| title_sort | recent advances in calcium peroxide nanomedicines for breast cancer treatment |
| topic | CaO2 Breast cancer ROS Hypoxia |
| url | https://doi.org/10.1007/s12672-025-03329-x |
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