Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems
Retinal diseases, such as age-related macular degeneration and diabetic macular edema, are significant contributors to vision loss. While injection of anti-vascular endothelial growth factors is the current gold standard treatment, their invasive nature reduces patient compliance and treatment outco...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2025-06-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0264382 |
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| author | Weiliang Wang Nancy Wang Xinxin Zhao Xinyi Su Zengping Liu |
| author_facet | Weiliang Wang Nancy Wang Xinxin Zhao Xinyi Su Zengping Liu |
| author_sort | Weiliang Wang |
| collection | DOAJ |
| description | Retinal diseases, such as age-related macular degeneration and diabetic macular edema, are significant contributors to vision loss. While injection of anti-vascular endothelial growth factors is the current gold standard treatment, their invasive nature reduces patient compliance and treatment outcomes and increases the risk of complications. In this review, we explore the recent advancements in drug delivery systems designed to overcome ocular barriers to effectively deliver drugs to the retina. We examine advancements in intravitreal injections, such as novel formulations, therapeutic molecules, and sustained-release implants. Moreover, we discuss innovations in noninvasive strategies, such as topical delivery systems incorporating cell-penetrating peptides, solid lipid nanoparticles, dendrimers, and nano-micelles. These technologies aim to enhance drug penetration, stability, and bioavailability. Although preclinical and clinical trials have yielded promising results, challenges remain in ensuring long-term safety and efficacy. This review highlights future research directions to optimize these approaches and develop more effective, patient-friendly therapies for retinal diseases. |
| format | Article |
| id | doaj-art-03cdad315f5e4196991f0c25d3c074ff |
| institution | OA Journals |
| issn | 2473-2877 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj-art-03cdad315f5e4196991f0c25d3c074ff2025-08-20T02:38:29ZengAIP Publishing LLCAPL Bioengineering2473-28772025-06-0192020902020902-1710.1063/5.0264382Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systemsWeiliang Wang0Nancy Wang1Xinxin Zhao2Xinyi Su3Zengping Liu4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeRetinal diseases, such as age-related macular degeneration and diabetic macular edema, are significant contributors to vision loss. While injection of anti-vascular endothelial growth factors is the current gold standard treatment, their invasive nature reduces patient compliance and treatment outcomes and increases the risk of complications. In this review, we explore the recent advancements in drug delivery systems designed to overcome ocular barriers to effectively deliver drugs to the retina. We examine advancements in intravitreal injections, such as novel formulations, therapeutic molecules, and sustained-release implants. Moreover, we discuss innovations in noninvasive strategies, such as topical delivery systems incorporating cell-penetrating peptides, solid lipid nanoparticles, dendrimers, and nano-micelles. These technologies aim to enhance drug penetration, stability, and bioavailability. Although preclinical and clinical trials have yielded promising results, challenges remain in ensuring long-term safety and efficacy. This review highlights future research directions to optimize these approaches and develop more effective, patient-friendly therapies for retinal diseases.http://dx.doi.org/10.1063/5.0264382 |
| spellingShingle | Weiliang Wang Nancy Wang Xinxin Zhao Xinyi Su Zengping Liu Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems APL Bioengineering |
| title | Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems |
| title_full | Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems |
| title_fullStr | Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems |
| title_full_unstemmed | Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems |
| title_short | Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems |
| title_sort | recent advancements in polymer science for retinal diseases new frontiers in drug delivery systems |
| url | http://dx.doi.org/10.1063/5.0264382 |
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