SERINC5 counters retroviruses and non-retroviruses
SERINC5 (serine incorporator 5), a member of the serine incorporator family, has been identified as a retrovirus restriction factor that inhibits the fusion of virions with the plasma membrane, thus blocking the release of the viral core into target cells and subsequently attenuating viral infectivi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1516806/full |
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| author | Jinghua Yu Jinghua Yu Jinghua Yu Chunyu Liu Xinglong Qu Xinglin Gao Yue Liu |
| author_facet | Jinghua Yu Jinghua Yu Jinghua Yu Chunyu Liu Xinglong Qu Xinglin Gao Yue Liu |
| author_sort | Jinghua Yu |
| collection | DOAJ |
| description | SERINC5 (serine incorporator 5), a member of the serine incorporator family, has been identified as a retrovirus restriction factor that inhibits the fusion of virions with the plasma membrane, thus blocking the release of the viral core into target cells and subsequently attenuating viral infectivity. Several viruses, such as human immunodeficiency virus (HIV), murine leukemia virus (MLV), and equine infectious anemia virus (EIAV), have evolved mechanisms to antagonize the host protein SERINC5 through HIV Nef, MLV glycosylated Gag, and the EIAV S2 protein. These viral proteins degrade SERINC5 on the cell surface through the endolysosomal system. In addition to its direct antiviral ability, SERINC5 also modulates immunity to inhibit the replication of retroviruses and nonretroviruses. This review summarizes the interaction between SERINC5 and viral replication, providing a promising avenue for fighting viral diseases. |
| format | Article |
| id | doaj-art-03c9fead29b04008ae518b281a4f0771 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-03c9fead29b04008ae518b281a4f07712025-01-20T05:23:52ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.15168061516806SERINC5 counters retroviruses and non-retrovirusesJinghua Yu0Jinghua Yu1Jinghua Yu2Chunyu Liu3Xinglong Qu4Xinglin Gao5Yue Liu6Department of Echocardiography, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaInfectious Diseases and Pathogen Biology Center, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaInstitute of Virology and AIDS Research, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaDepartment of Acupuncture, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, ChinaRespiratory Department of the First Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaDepartment of Urology, Siping Central People’s Hospital, Siping, Jilin, ChinaDepartment of Echocardiography, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, ChinaSERINC5 (serine incorporator 5), a member of the serine incorporator family, has been identified as a retrovirus restriction factor that inhibits the fusion of virions with the plasma membrane, thus blocking the release of the viral core into target cells and subsequently attenuating viral infectivity. Several viruses, such as human immunodeficiency virus (HIV), murine leukemia virus (MLV), and equine infectious anemia virus (EIAV), have evolved mechanisms to antagonize the host protein SERINC5 through HIV Nef, MLV glycosylated Gag, and the EIAV S2 protein. These viral proteins degrade SERINC5 on the cell surface through the endolysosomal system. In addition to its direct antiviral ability, SERINC5 also modulates immunity to inhibit the replication of retroviruses and nonretroviruses. This review summarizes the interaction between SERINC5 and viral replication, providing a promising avenue for fighting viral diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1516806/fullSERINC5human immunodeficiency virus 1retrovirusesnonretrovirusesvirus-host interaction |
| spellingShingle | Jinghua Yu Jinghua Yu Jinghua Yu Chunyu Liu Xinglong Qu Xinglin Gao Yue Liu SERINC5 counters retroviruses and non-retroviruses Frontiers in Cellular and Infection Microbiology SERINC5 human immunodeficiency virus 1 retroviruses nonretroviruses virus-host interaction |
| title | SERINC5 counters retroviruses and non-retroviruses |
| title_full | SERINC5 counters retroviruses and non-retroviruses |
| title_fullStr | SERINC5 counters retroviruses and non-retroviruses |
| title_full_unstemmed | SERINC5 counters retroviruses and non-retroviruses |
| title_short | SERINC5 counters retroviruses and non-retroviruses |
| title_sort | serinc5 counters retroviruses and non retroviruses |
| topic | SERINC5 human immunodeficiency virus 1 retroviruses nonretroviruses virus-host interaction |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1516806/full |
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