Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value

Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value

Liposarcoma (LPS) is the most common soft-tissue sarcoma in adults, and well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are the most frequent subtypes. These LPSs are considered to develop due to disturbances in the adipogenic differentiation of mesenchymal stem cell...

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Bibliographic Details
Main Authors: Naoko Hattori, Hironori Takamatsu, Naoko Iida, Naofumi Asano, Satoshi Yamashita, Gina Miku Oba, Kozue Kimura, Akihiko Yoshida, Eisuke Kobayashi, Robert Nakayama, Morio Matsumoto, Masaya Nakamura, Akira Kawai, Toshikazu Ushijima
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
epigenome
DNA methylation
sarcoma
adipogenic differentiation
DNA demethylating agent
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1419877/full
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