Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis
Purpose: To evaluate the potential clinical role and reliability of Sonazoid-enhanced ultrasound (SEUS) as a diagnostic tool for liver metastatic lesions. Methods: An extensive literature search was conducted across five electronic databases, PubMed, Scopus, Embase, Cochrane Library, and Web of Scie...
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2025-04-01
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| author | Anas Elgenidy Khaled Saad Reda Ibrahim Aya Sherif Taher Elmozugi Moaz Y. Darwish Mahmoud Abbas Yousif A. Othman Abdelrahman Elshimy Alyaa M. Sheir Dina H. Khattab Abdallah A. Helal Mario M. Tawadros Osama Abuel-naga Hazem I. Abdel-Rahman Doaa Ali Gamal Amira Elhoufey Hamad Ghaleb Dailah Rami A. Metwally Noran ElBazzar Hashem Abu Serhan |
| author_facet | Anas Elgenidy Khaled Saad Reda Ibrahim Aya Sherif Taher Elmozugi Moaz Y. Darwish Mahmoud Abbas Yousif A. Othman Abdelrahman Elshimy Alyaa M. Sheir Dina H. Khattab Abdallah A. Helal Mario M. Tawadros Osama Abuel-naga Hazem I. Abdel-Rahman Doaa Ali Gamal Amira Elhoufey Hamad Ghaleb Dailah Rami A. Metwally Noran ElBazzar Hashem Abu Serhan |
| author_sort | Anas Elgenidy |
| collection | DOAJ |
| description | Purpose: To evaluate the potential clinical role and reliability of Sonazoid-enhanced ultrasound (SEUS) as a diagnostic tool for liver metastatic lesions. Methods: An extensive literature search was conducted across five electronic databases, PubMed, Scopus, Embase, Cochrane Library, and Web of Science, from their inception up to January 2024 to identify all studies evaluating the use of Sonazoid-enhanced ultrasonography for detecting hepatic metastases. A meta-analysis was performed to assess diagnostic accuracy using the Meta-DiSc 2.0 software. Results: A total of 31 studies were included, 16 of which were eligible for meta-analysis and diagnostic test accuracy evaluation. A total of 13 studies in the meta-analysis evaluated the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) for 1347 metastatic and 1565 non-metastatic liver lesions. The pooled sensitivity and specificity for CEUS were 0.88 (95% CI: 0.82–0.92) and 0.92 (95% CI: 0.84–0.96), respectively. The combined positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 11.89 (95% CI: 5.42–26.09), 0.12 (95% CI:0.08–0.19), and 91.99 (95% CI: 32.15–263.17), respectively. Additionally, four studies of the meta-analysis assessed the diagnostic performance of contrast-enhanced intraoperative sonography (CE-IOUS) in detecting 664 metastatic and 246 non-metastatic liver lesions. The pooled sensitivity and specificity for CE-IOUS were 0.93 (95% CI: 0.82–0.97) and 0.84 (95% CI: 0.65–0.93), respectively. The aggregated positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were calculated as 5.95 (95% CI: 2.32–15.25), 0.07 (95% CI: 0.02–0.24), and 77.68 (95% CI: 10.33–583.86), respectively. Conclusions: CE-IOUS and CEUS are reliable approaches for diagnosing liver metastatic lesions. CE-IOUS, in particular, exhibits higher accuracy in identifying liver metastatic lesions, indicating its potential effectiveness in clinical practice. |
| format | Article |
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| institution | OA Journals |
| issn | 2076-3271 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Medical Sciences |
| spelling | doaj-art-03c5ba5c427b476bbe5ea7b03a91ded62025-08-20T02:21:04ZengMDPI AGMedical Sciences2076-32712025-04-011324210.3390/medsci13020042Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver MetastasisAnas Elgenidy0Khaled Saad1Reda Ibrahim2Aya Sherif3Taher Elmozugi4Moaz Y. Darwish5Mahmoud Abbas6Yousif A. Othman7Abdelrahman Elshimy8Alyaa M. Sheir9Dina H. Khattab10Abdallah A. Helal11Mario M. Tawadros12Osama Abuel-naga13Hazem I. Abdel-Rahman14Doaa Ali Gamal15Amira Elhoufey16Hamad Ghaleb Dailah17Rami A. Metwally18Noran ElBazzar19Hashem Abu Serhan20Faculty of Medicine, Cairo University, Cairo 12613, EgyptPediatric Department, Faculty of Medicine, Assiut University, Assiut 71516, EgyptFaculty of Medicine, Cairo University, Cairo 12613, EgyptFaculty of Medicine, Beni Suef University, Beni Suef 62511, EgyptFaculty of Medicine, Benghazi University, Benghazi 18251, LibyaFaculty of Medicine, Fayoum University, Fayoum 63514, EgyptDepartment of Radiology, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USAFaculty of Medicine, Fayoum University, Fayoum 63514, EgyptFaculty of Medicine, Alexandria University, Alexandria 21526, EgyptFaculty of Medicine, Ain Shams University, Cairo 11591, EgyptFaculty of Medicine, Cairo University, Cairo 12613, EgyptFaculty of Medicine, Fayoum University, Fayoum 63514, EgyptFaculty of Medicine, Cairo University, Cairo 12613, EgyptDepartment of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11591, EgyptDepartment of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11591, EgyptClinical Oncology Department, Faculty of Medicine, Assiut University, Assiut 71516, EgyptDepartment of Community Health Nursing, Alddrab University College, Jazan University, Jazan 45142, Saudi ArabiaResearch and Scientific Studies Unit, College of Nursing, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Internal Medicine, Benha University, Benha 13511, EgyptDepartment of Internal Medicine, Benha University, Benha 13511, EgyptDepartment of Ophthalmology, Hamad Medical Corporation, Doha 3050, QatarPurpose: To evaluate the potential clinical role and reliability of Sonazoid-enhanced ultrasound (SEUS) as a diagnostic tool for liver metastatic lesions. Methods: An extensive literature search was conducted across five electronic databases, PubMed, Scopus, Embase, Cochrane Library, and Web of Science, from their inception up to January 2024 to identify all studies evaluating the use of Sonazoid-enhanced ultrasonography for detecting hepatic metastases. A meta-analysis was performed to assess diagnostic accuracy using the Meta-DiSc 2.0 software. Results: A total of 31 studies were included, 16 of which were eligible for meta-analysis and diagnostic test accuracy evaluation. A total of 13 studies in the meta-analysis evaluated the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) for 1347 metastatic and 1565 non-metastatic liver lesions. The pooled sensitivity and specificity for CEUS were 0.88 (95% CI: 0.82–0.92) and 0.92 (95% CI: 0.84–0.96), respectively. The combined positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 11.89 (95% CI: 5.42–26.09), 0.12 (95% CI:0.08–0.19), and 91.99 (95% CI: 32.15–263.17), respectively. Additionally, four studies of the meta-analysis assessed the diagnostic performance of contrast-enhanced intraoperative sonography (CE-IOUS) in detecting 664 metastatic and 246 non-metastatic liver lesions. The pooled sensitivity and specificity for CE-IOUS were 0.93 (95% CI: 0.82–0.97) and 0.84 (95% CI: 0.65–0.93), respectively. The aggregated positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were calculated as 5.95 (95% CI: 2.32–15.25), 0.07 (95% CI: 0.02–0.24), and 77.68 (95% CI: 10.33–583.86), respectively. Conclusions: CE-IOUS and CEUS are reliable approaches for diagnosing liver metastatic lesions. CE-IOUS, in particular, exhibits higher accuracy in identifying liver metastatic lesions, indicating its potential effectiveness in clinical practice.https://www.mdpi.com/2076-3271/13/2/42hepatocellular carcinomaliver metastasisSonazoidultrasonography |
| spellingShingle | Anas Elgenidy Khaled Saad Reda Ibrahim Aya Sherif Taher Elmozugi Moaz Y. Darwish Mahmoud Abbas Yousif A. Othman Abdelrahman Elshimy Alyaa M. Sheir Dina H. Khattab Abdallah A. Helal Mario M. Tawadros Osama Abuel-naga Hazem I. Abdel-Rahman Doaa Ali Gamal Amira Elhoufey Hamad Ghaleb Dailah Rami A. Metwally Noran ElBazzar Hashem Abu Serhan Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis Medical Sciences hepatocellular carcinoma liver metastasis Sonazoid ultrasonography |
| title | Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis |
| title_full | Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis |
| title_fullStr | Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis |
| title_full_unstemmed | Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis |
| title_short | Diagnostic Accuracy of Sonazoid-Enhanced Ultrasonography for Detection of Liver Metastasis |
| title_sort | diagnostic accuracy of sonazoid enhanced ultrasonography for detection of liver metastasis |
| topic | hepatocellular carcinoma liver metastasis Sonazoid ultrasonography |
| url | https://www.mdpi.com/2076-3271/13/2/42 |
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