U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study
ObjectiveWe conducted this study to investigate the relationship between serum uric acid (SUA) levels and the risk of upper gastrointestinal cancer.MethodsWe conducted a prospective cohort study with 475659 cancer-free participants from the UK Biobank. All subjects were grouped into quartiles, and w...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1482814/full |
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| author | Junjun Huang Ningning Mi Jingli Yang Ya Zheng Jinqiu Yuan Jinqiu Yuan Wenbo Meng Wenbo Meng Wenbo Meng Wenbo Meng Wenbo Meng |
| author_facet | Junjun Huang Ningning Mi Jingli Yang Ya Zheng Jinqiu Yuan Jinqiu Yuan Wenbo Meng Wenbo Meng Wenbo Meng Wenbo Meng Wenbo Meng |
| author_sort | Junjun Huang |
| collection | DOAJ |
| description | ObjectiveWe conducted this study to investigate the relationship between serum uric acid (SUA) levels and the risk of upper gastrointestinal cancer.MethodsWe conducted a prospective cohort study with 475659 cancer-free participants from the UK Biobank. All subjects were grouped into quartiles, and we used a Cox proportional hazards model to analyze the association between SUA levels and the risk of upper gastrointestinal cancer and explore the potential sex-specific relationship.ResultsOf the 475659 participants, 883 eventually developed upper gastrointestinal cancers over a median follow-up period of 6.7 years. We observed that SUA level was positively correlated with the risk of female oral cancer (hazard ratio Quartile 4 vs Quartile 1 (95% CI): 2.05(1.03,4.06)) and negatively associated with the risk of esophageal cancer in the general population (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 0.65(0.45,0.93)). The risk of gastric cancer in males showed a U-shaped trend, decreasing and then increasing as SUA levels increased (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 0.51(0.32,0.81)). The risk of small intestine cancer in females showed a trend of increasing and then decreasing with increasing SUA levels (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 3.34(1.10,10.13)). Interaction analysis indicated that various factors, such as age, sex, smoking and drinking status, family history of cancer and BMI might play an important role in the relationship between SUA and cancer.ConclusionSUA levels are positively associated with the risk of oral cancer risk in females and negatively associated with the risk of esophageal cancer in the general population. Both low and high SUA levels were associated with increased risk of gastric cancer, supporting a U-shaped association. |
| format | Article |
| id | doaj-art-03c00f92d0be4a349ca5e6107b47d606 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-03c00f92d0be4a349ca5e6107b47d6062025-08-20T02:31:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.14828141482814U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort studyJunjun Huang0Ningning Mi1Jingli Yang2Ya Zheng3Jinqiu Yuan4Jinqiu Yuan5Wenbo Meng6Wenbo Meng7Wenbo Meng8Wenbo Meng9Wenbo Meng10Scientific research & Planning Department, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou, ChinaCollege of Earth and Environmental Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaClinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, ChinaInstitute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaGansu Province Institute of Hepatopancreatobiliary, Lanzhou, China0Gansu Province Key Laboratory Biotherapy and Regenerative Medicine, Lanzhou, ChinaObjectiveWe conducted this study to investigate the relationship between serum uric acid (SUA) levels and the risk of upper gastrointestinal cancer.MethodsWe conducted a prospective cohort study with 475659 cancer-free participants from the UK Biobank. All subjects were grouped into quartiles, and we used a Cox proportional hazards model to analyze the association between SUA levels and the risk of upper gastrointestinal cancer and explore the potential sex-specific relationship.ResultsOf the 475659 participants, 883 eventually developed upper gastrointestinal cancers over a median follow-up period of 6.7 years. We observed that SUA level was positively correlated with the risk of female oral cancer (hazard ratio Quartile 4 vs Quartile 1 (95% CI): 2.05(1.03,4.06)) and negatively associated with the risk of esophageal cancer in the general population (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 0.65(0.45,0.93)). The risk of gastric cancer in males showed a U-shaped trend, decreasing and then increasing as SUA levels increased (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 0.51(0.32,0.81)). The risk of small intestine cancer in females showed a trend of increasing and then decreasing with increasing SUA levels (hazard ratio Quartile 3 vs Quartile 1 (95% CI): 3.34(1.10,10.13)). Interaction analysis indicated that various factors, such as age, sex, smoking and drinking status, family history of cancer and BMI might play an important role in the relationship between SUA and cancer.ConclusionSUA levels are positively associated with the risk of oral cancer risk in females and negatively associated with the risk of esophageal cancer in the general population. Both low and high SUA levels were associated with increased risk of gastric cancer, supporting a U-shaped association.https://www.frontiersin.org/articles/10.3389/fonc.2024.1482814/fullupper gastrointestinal canceruric acidUK biobankcohort studyU-shaped relationship |
| spellingShingle | Junjun Huang Ningning Mi Jingli Yang Ya Zheng Jinqiu Yuan Jinqiu Yuan Wenbo Meng Wenbo Meng Wenbo Meng Wenbo Meng Wenbo Meng U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study Frontiers in Oncology upper gastrointestinal cancer uric acid UK biobank cohort study U-shaped relationship |
| title | U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study |
| title_full | U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study |
| title_fullStr | U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study |
| title_full_unstemmed | U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study |
| title_short | U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study |
| title_sort | u shaped relationship between serum uric acid and gastric cancer risk a large prospective cohort study |
| topic | upper gastrointestinal cancer uric acid UK biobank cohort study U-shaped relationship |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1482814/full |
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