Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy
Predominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient. This underglycosylated IgA may play an important role in the pathogenesis of IgAN....
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/470803 |
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| author | Mototsugu Tanaka George Seki Tomonosuke Someya Michio Nagata Toshiro Fujita |
| author_facet | Mototsugu Tanaka George Seki Tomonosuke Someya Michio Nagata Toshiro Fujita |
| author_sort | Mototsugu Tanaka |
| collection | DOAJ |
| description | Predominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient. This underglycosylated IgA may play an important role in the pathogenesis of IgAN. Recently, antibodies against galactose-deficient IgA1 were found to be well associated with the development of IgAN. Several therapeutic strategies based on corticosteroids or other immunosuppressive agents have been shown to at least partially suppress the progression of IgAN. On the other hand, several case reports of kidney transplantation or acquired IgA deficiency uncovered a remarkable ability of human kidney to remove mesangial IgA deposition, resulting in the long-term stabilization of kidney function. Continuous exposure to circulating immune complexes containing aberrantly glycosylated IgA1 and sequential immune response seems to be essential in the disease progression of IgAN. Removal of mesangial IgA deposition may be a challenging, but fundamental approach in the treatment of IgAN. |
| format | Article |
| id | doaj-art-03bebccfb6b44244a656303b19080f97 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-03bebccfb6b44244a656303b19080f972025-08-20T03:54:14ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/470803470803Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA NephropathyMototsugu Tanaka0George Seki1Tomonosuke Someya2Michio Nagata3Toshiro Fujita4Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Pediatrics, Juntendo University School of Medicine, Tokyo 113-8431, JapanMolecular Pathology, Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, JapanDepartment of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanPredominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 subclass and usually galactose-deficient. This underglycosylated IgA may play an important role in the pathogenesis of IgAN. Recently, antibodies against galactose-deficient IgA1 were found to be well associated with the development of IgAN. Several therapeutic strategies based on corticosteroids or other immunosuppressive agents have been shown to at least partially suppress the progression of IgAN. On the other hand, several case reports of kidney transplantation or acquired IgA deficiency uncovered a remarkable ability of human kidney to remove mesangial IgA deposition, resulting in the long-term stabilization of kidney function. Continuous exposure to circulating immune complexes containing aberrantly glycosylated IgA1 and sequential immune response seems to be essential in the disease progression of IgAN. Removal of mesangial IgA deposition may be a challenging, but fundamental approach in the treatment of IgAN.http://dx.doi.org/10.1155/2011/470803 |
| spellingShingle | Mototsugu Tanaka George Seki Tomonosuke Someya Michio Nagata Toshiro Fujita Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy Clinical and Developmental Immunology |
| title | Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy |
| title_full | Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy |
| title_fullStr | Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy |
| title_full_unstemmed | Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy |
| title_short | Aberrantly Glycosylated IgA1 as a Factor in the Pathogenesis of IgA Nephropathy |
| title_sort | aberrantly glycosylated iga1 as a factor in the pathogenesis of iga nephropathy |
| url | http://dx.doi.org/10.1155/2011/470803 |
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