IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS
Objective: to analyze some parameters of cellular and humoral immunity and peripheral blood cytokines in patients with grade III idiopathic gonarthrosis, as well as to identify most significant laboratory immunological tests indicating the activity of articular tissue degradation. Materials and met...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Private institution educational organization of higher education "Medical University "ReaViz"
2021-02-01
|
| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849244192568508416 |
|---|---|
| author | I. A. Mamonova O. A. Kauts Yu. A. Barabash S. P. Shpinyak K. A. Grazhdanov |
| author_facet | I. A. Mamonova O. A. Kauts Yu. A. Barabash S. P. Shpinyak K. A. Grazhdanov |
| author_sort | I. A. Mamonova |
| collection | DOAJ |
| description | Objective: to analyze some parameters of cellular and humoral immunity and peripheral blood cytokines in patients with grade III idiopathic gonarthrosis, as well as to identify most significant laboratory immunological tests indicating the activity of articular tissue degradation. Materials and methods. We assessed laboratory parameters reflecting the immune status in 20 patients with grade III idiopathic gonarthrosis (18 males and 2 females; mean age 64.1 years (range 58.6; 62.1 years). Results. We observed some immunological changes in peripheral blood of patients with grade III gonarthrosis, such as a decrease in the T cell count (T-helpers and T-suppressors), B cell count, and in the level of immunoglobulins G along with an increase in the count of natural killers, levels of serum immunoglobulin A, and proinflammatory (TNFa, IL-6) and antiinflammatory (IL-10, IL-4) cytokines. Conclusion. Degenerative dystrophic changes in the knee joint affect the immune status of patients with grade III gonarthrosis. It is necessary to evaluate parameters of cellular and humoral immunity of patients with advanced gonarthrosis before surgical interventions in order to minimize the risks of early and late postoperative complications. |
| format | Article |
| id | doaj-art-03bd10e678e64856b3c75a42a83edae0 |
| institution | Kabale University |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2021-02-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-03bd10e678e64856b3c75a42a83edae02025-08-20T03:59:13ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792021-02-010510211010.20340/vmi-rvz.2020.5.11123IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSISI. A. Mamonova0O. A. Kauts1Yu. A. Barabash2S. P. Shpinyak3K. A. Grazhdanov4Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian FederationFederal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian FederationFederal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian FederationFederal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian FederationFederal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian FederationObjective: to analyze some parameters of cellular and humoral immunity and peripheral blood cytokines in patients with grade III idiopathic gonarthrosis, as well as to identify most significant laboratory immunological tests indicating the activity of articular tissue degradation. Materials and methods. We assessed laboratory parameters reflecting the immune status in 20 patients with grade III idiopathic gonarthrosis (18 males and 2 females; mean age 64.1 years (range 58.6; 62.1 years). Results. We observed some immunological changes in peripheral blood of patients with grade III gonarthrosis, such as a decrease in the T cell count (T-helpers and T-suppressors), B cell count, and in the level of immunoglobulins G along with an increase in the count of natural killers, levels of serum immunoglobulin A, and proinflammatory (TNFa, IL-6) and antiinflammatory (IL-10, IL-4) cytokines. Conclusion. Degenerative dystrophic changes in the knee joint affect the immune status of patients with grade III gonarthrosis. It is necessary to evaluate parameters of cellular and humoral immunity of patients with advanced gonarthrosis before surgical interventions in order to minimize the risks of early and late postoperative complications.https://vestnik.reaviz.ru/jour/article/view/122idiopathic osteoarthritiscellular immunityhumoral immunitycytokines |
| spellingShingle | I. A. Mamonova O. A. Kauts Yu. A. Barabash S. P. Shpinyak K. A. Grazhdanov IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье idiopathic osteoarthritis cellular immunity humoral immunity cytokines |
| title | IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS |
| title_full | IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS |
| title_fullStr | IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS |
| title_full_unstemmed | IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS |
| title_short | IMMUNE STATUS OF PATIENTS WITH GRADE III IDIOPATHIC GONARTHROSIS |
| title_sort | immune status of patients with grade iii idiopathic gonarthrosis |
| topic | idiopathic osteoarthritis cellular immunity humoral immunity cytokines |
| url | https://vestnik.reaviz.ru/jour/article/view/122 |
| work_keys_str_mv | AT iamamonova immunestatusofpatientswithgradeiiiidiopathicgonarthrosis AT oakauts immunestatusofpatientswithgradeiiiidiopathicgonarthrosis AT yuabarabash immunestatusofpatientswithgradeiiiidiopathicgonarthrosis AT spshpinyak immunestatusofpatientswithgradeiiiidiopathicgonarthrosis AT kagrazhdanov immunestatusofpatientswithgradeiiiidiopathicgonarthrosis |