Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications
Abstract Hepatocellular carcinoma features extensive metabolic reprogramming. This includes alterations in major biochemical pathways such as glycolysis, the pentose phosphate pathway, amino acid metabolism and fatty acid metabolism. Moreover, there is a complex interplay among these altered pathway...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-03-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-025-01415-2 |
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| _version_ | 1850268665704873984 |
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| author | Sujin Park Michael N. Hall |
| author_facet | Sujin Park Michael N. Hall |
| author_sort | Sujin Park |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma features extensive metabolic reprogramming. This includes alterations in major biochemical pathways such as glycolysis, the pentose phosphate pathway, amino acid metabolism and fatty acid metabolism. Moreover, there is a complex interplay among these altered pathways, particularly involving acetyl-CoA (coenzyme-A) metabolism and redox homeostasis, which in turn influences reprogramming of other metabolic pathways. Understanding these metabolic changes and their interactions with cellular signaling pathways offers potential strategies for the targeted treatment of hepatocellular carcinoma and improved patient outcomes. This review explores the specific metabolic alterations observed in hepatocellular carcinoma and highlights their roles in the progression of the disease. |
| format | Article |
| id | doaj-art-03baef2aba2346e79a85400aec87a5f3 |
| institution | OA Journals |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-03baef2aba2346e79a85400aec87a5f32025-08-20T01:53:23ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-03-0157351552310.1038/s12276-025-01415-2Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implicationsSujin Park0Michael N. Hall1Center for Genome Engineering, Institute for Basic ScienceBiozentrum, University of BaselAbstract Hepatocellular carcinoma features extensive metabolic reprogramming. This includes alterations in major biochemical pathways such as glycolysis, the pentose phosphate pathway, amino acid metabolism and fatty acid metabolism. Moreover, there is a complex interplay among these altered pathways, particularly involving acetyl-CoA (coenzyme-A) metabolism and redox homeostasis, which in turn influences reprogramming of other metabolic pathways. Understanding these metabolic changes and their interactions with cellular signaling pathways offers potential strategies for the targeted treatment of hepatocellular carcinoma and improved patient outcomes. This review explores the specific metabolic alterations observed in hepatocellular carcinoma and highlights their roles in the progression of the disease.https://doi.org/10.1038/s12276-025-01415-2 |
| spellingShingle | Sujin Park Michael N. Hall Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications Experimental and Molecular Medicine |
| title | Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications |
| title_full | Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications |
| title_fullStr | Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications |
| title_full_unstemmed | Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications |
| title_short | Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications |
| title_sort | metabolic reprogramming in hepatocellular carcinoma mechanisms and therapeutic implications |
| url | https://doi.org/10.1038/s12276-025-01415-2 |
| work_keys_str_mv | AT sujinpark metabolicreprogramminginhepatocellularcarcinomamechanismsandtherapeuticimplications AT michaelnhall metabolicreprogramminginhepatocellularcarcinomamechanismsandtherapeuticimplications |