Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis
The article presents a case of using genetically engineered biopharmaceutical tocilizumab in a child with systemic juvenile idiopathic arthritis. On the initial stage, the treatment was characterized by resistance to high doses of glucocorticoids and cytostatic drugs. Successful termination of visce...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2016-02-01
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| Series: | Педиатрическая фармакология |
| Subjects: | |
| Online Access: | https://www.pedpharma.ru/jour/article/view/1371 |
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| author | Y. M. Spivakovskiy Y. V. Chernenkov A. Y. Spivakovskaya O. V. Skupova E. N. Shulgina |
| author_facet | Y. M. Spivakovskiy Y. V. Chernenkov A. Y. Spivakovskaya O. V. Skupova E. N. Shulgina |
| author_sort | Y. M. Spivakovskiy |
| collection | DOAJ |
| description | The article presents a case of using genetically engineered biopharmaceutical tocilizumab in a child with systemic juvenile idiopathic arthritis. On the initial stage, the treatment was characterized by resistance to high doses of glucocorticoids and cytostatic drugs. Successful termination of visceral and articular manifestations of systemic juvenile idiopathic arthritis and normalization of laboratory indicators of disease activity in the setting of use of interleukin 6 receptor blocker were described. We observed stable improvement of the child’s condition during a year-long follow-up in the setting of the selected anti-inflammatory therapy pattern. |
| format | Article |
| id | doaj-art-03b722ec9a7b4e8aaa034de25b1d9514 |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-03b722ec9a7b4e8aaa034de25b1d95142025-08-20T03:19:41ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892016-02-0112667267610.15690/pf.v12i6.14911363Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic ArthritisY. M. Spivakovskiy0Y. V. Chernenkov1A. Y. Spivakovskaya2O. V. Skupova3E. N. Shulgina4Razumovskiy Saratov State Medical University, Saratov, Russian FederationRazumovskiy Saratov State Medical University, Saratov, Russian FederationRazumovskiy Saratov State Medical University, Saratov, Russian FederationRazumovskiy Saratov State Medical University, Saratov, Russian FederationRazumovskiy Saratov State Medical University, Saratov, Russian FederationThe article presents a case of using genetically engineered biopharmaceutical tocilizumab in a child with systemic juvenile idiopathic arthritis. On the initial stage, the treatment was characterized by resistance to high doses of glucocorticoids and cytostatic drugs. Successful termination of visceral and articular manifestations of systemic juvenile idiopathic arthritis and normalization of laboratory indicators of disease activity in the setting of use of interleukin 6 receptor blocker were described. We observed stable improvement of the child’s condition during a year-long follow-up in the setting of the selected anti-inflammatory therapy pattern.https://www.pedpharma.ru/jour/article/view/1371juvenile idiopathic arthritissystemic variantgenetically engineered biopharmaceuticalstocilizumab |
| spellingShingle | Y. M. Spivakovskiy Y. V. Chernenkov A. Y. Spivakovskaya O. V. Skupova E. N. Shulgina Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis Педиатрическая фармакология juvenile idiopathic arthritis systemic variant genetically engineered biopharmaceuticals tocilizumab |
| title | Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis |
| title_full | Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis |
| title_fullStr | Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis |
| title_short | Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis |
| title_sort | clinical case of tocilizumab use in a patient with systemic juvenile idiopathic arthritis |
| topic | juvenile idiopathic arthritis systemic variant genetically engineered biopharmaceuticals tocilizumab |
| url | https://www.pedpharma.ru/jour/article/view/1371 |
| work_keys_str_mv | AT ymspivakovskiy clinicalcaseoftocilizumabuseinapatientwithsystemicjuvenileidiopathicarthritis AT yvchernenkov clinicalcaseoftocilizumabuseinapatientwithsystemicjuvenileidiopathicarthritis AT ayspivakovskaya clinicalcaseoftocilizumabuseinapatientwithsystemicjuvenileidiopathicarthritis AT ovskupova clinicalcaseoftocilizumabuseinapatientwithsystemicjuvenileidiopathicarthritis AT enshulgina clinicalcaseoftocilizumabuseinapatientwithsystemicjuvenileidiopathicarthritis |