POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY
Aim. To reveal the relation of gene polymorphisms of interleukin-6 (IL6, C174G), interleukin-10 (IL10, C592A), superoxide dismutase (SOD1, G8958A) and angiotensin converting enzyme (ACE, Alu Ins/Del) with postsurgery atrial fibrillation (PSAF) after coronary bypass grafting (CBG) in coronary heart d...
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«FIRMA «SILICEA» LLC
2016-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/499 |
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| author | O. A. Rubanenko O. V. Fatenkov S. M. Khokhlunov S. A. Shavkunov |
| author_facet | O. A. Rubanenko O. V. Fatenkov S. M. Khokhlunov S. A. Shavkunov |
| author_sort | O. A. Rubanenko |
| collection | DOAJ |
| description | Aim. To reveal the relation of gene polymorphisms of interleukin-6 (IL6, C174G), interleukin-10 (IL10, C592A), superoxide dismutase (SOD1, G8958A) and angiotensin converting enzyme (ACE, Alu Ins/Del) with postsurgery atrial fibrillation (PSAF) after coronary bypass grafting (CBG) in coronary heart disease patients (CHD).Material and methods. Totally, 80 CHD patients studied, had been admitted for CBG. Genotype assessed for IL6 C174G, IL10 C592A, SOD1 G8958A and ACE Alu Ins/Del. According to PSAF, patients were selected to 2 groups: 1 group — non- PSAF (56 patients, 78,6% males, mean age 61,0±7,5 years), 2 group — with PSAF (24 patients, 83,3% males, mean age 64,7±7,9 years).Results. Analysis of genetic polymorphisms showed the prevalence of СG IL6 C174G (57,2%) genotype, СС IL10 C592A (62,5%), GG SOD1 G8958A (87,5%), I/D ACE Alu Ins/Del (60,8%) among non-arrhythmic patients. In PSAF most prevalent were genotypes СG IL6 C174G (54,2%), СА IL10 C592A (54,2%), GG SOD1 G8958A (79,2%), I/D ACE Alu (58,4%). In multifactor regression analysis, odds ratio for PSAF in allele G IL6 C174G was 1,5 (95% CI, 0,69-3,44, р=0,29), for allele A IL10 C592A — 2,7 (95% CI, 1,2-6,9, р=0,04), for allele A SOD1 G8958A — 2,1 (95% CI, 0,7-6,2, р=0,19), for allele D gene ACE Alu Ins/Del — 0,9 (95% CI, 0,27-3,1, р=0,89).Conclusion. Therefore, presence of allele A of candidate gene IL10 C592A might force the onset of atrial fibrillation during early postsurgery period in coronary bypass. |
| format | Article |
| id | doaj-art-03b6044a00054ee8958d09704084fad0 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2016-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-03b6044a00054ee8958d09704084fad02025-08-20T02:59:38Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202016-10-01010374210.15829/1560-4071-2016-10-37-42504POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERYO. A. Rubanenko0O. V. Fatenkov1S. M. Khokhlunov2S. A. Shavkunov3Samara State Medical University of the Ministry of Health, Samara, Russia Samara Region Clinical Dispensary of CardiologySamara State Medical University of the Ministry of Health, Samara, RussiaSamara State Medical University of the Ministry of Health, Samara, Russia Samara Region Clinical Dispensary of CardiologyMunicipal Medical Institution of Samara Region Medical-Sanitary Dept. №2, Samara, RussiaAim. To reveal the relation of gene polymorphisms of interleukin-6 (IL6, C174G), interleukin-10 (IL10, C592A), superoxide dismutase (SOD1, G8958A) and angiotensin converting enzyme (ACE, Alu Ins/Del) with postsurgery atrial fibrillation (PSAF) after coronary bypass grafting (CBG) in coronary heart disease patients (CHD).Material and methods. Totally, 80 CHD patients studied, had been admitted for CBG. Genotype assessed for IL6 C174G, IL10 C592A, SOD1 G8958A and ACE Alu Ins/Del. According to PSAF, patients were selected to 2 groups: 1 group — non- PSAF (56 patients, 78,6% males, mean age 61,0±7,5 years), 2 group — with PSAF (24 patients, 83,3% males, mean age 64,7±7,9 years).Results. Analysis of genetic polymorphisms showed the prevalence of СG IL6 C174G (57,2%) genotype, СС IL10 C592A (62,5%), GG SOD1 G8958A (87,5%), I/D ACE Alu Ins/Del (60,8%) among non-arrhythmic patients. In PSAF most prevalent were genotypes СG IL6 C174G (54,2%), СА IL10 C592A (54,2%), GG SOD1 G8958A (79,2%), I/D ACE Alu (58,4%). In multifactor regression analysis, odds ratio for PSAF in allele G IL6 C174G was 1,5 (95% CI, 0,69-3,44, р=0,29), for allele A IL10 C592A — 2,7 (95% CI, 1,2-6,9, р=0,04), for allele A SOD1 G8958A — 2,1 (95% CI, 0,7-6,2, р=0,19), for allele D gene ACE Alu Ins/Del — 0,9 (95% CI, 0,27-3,1, р=0,89).Conclusion. Therefore, presence of allele A of candidate gene IL10 C592A might force the onset of atrial fibrillation during early postsurgery period in coronary bypass.https://russjcardiol.elpub.ru/jour/article/view/499atrial fibrillationcoronary bypasspolymorphismgenesinterleukinssuperoxide dismutaseangiotensine converting enzyme |
| spellingShingle | O. A. Rubanenko O. V. Fatenkov S. M. Khokhlunov S. A. Shavkunov POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY Российский кардиологический журнал atrial fibrillation coronary bypass polymorphism genes interleukins superoxide dismutase angiotensine converting enzyme |
| title | POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY |
| title_full | POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY |
| title_fullStr | POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY |
| title_full_unstemmed | POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY |
| title_short | POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY |
| title_sort | polymorphism of the interleukin 6 interleukin 10 superoxide dismutase and angiotensin converting enzyme genes and the risk of atrial fibrillation after cardiosurgery |
| topic | atrial fibrillation coronary bypass polymorphism genes interleukins superoxide dismutase angiotensine converting enzyme |
| url | https://russjcardiol.elpub.ru/jour/article/view/499 |
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