Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management

Capgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her decease...

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Main Authors: Manuel Glauco Carbone, Tommaso Merati, Rossella Miccichè, Camilla Callegari, Beniamino Tripodi, Claudia Tagliarini, Icro Maremmani, Donatella Marazziti
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/crps/5541100
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author Manuel Glauco Carbone
Tommaso Merati
Rossella Miccichè
Camilla Callegari
Beniamino Tripodi
Claudia Tagliarini
Icro Maremmani
Donatella Marazziti
author_facet Manuel Glauco Carbone
Tommaso Merati
Rossella Miccichè
Camilla Callegari
Beniamino Tripodi
Claudia Tagliarini
Icro Maremmani
Donatella Marazziti
author_sort Manuel Glauco Carbone
collection DOAJ
description Capgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her deceased husband had been replaced by an imposter. The clinical presentation was complex, including pronounced sleep disturbances, cognitive decline, behavioral anomalies, and visual hallucinations, necessitating a thorough differential diagnosis process. We detail the patient’s history, clinical findings, and the investigations undertaken, including brain imaging and cognitive assessments. The management approach involved a personalized treatment plan integrating Lithium sulfate, Citalopram, and Lurasidone, alongside psychosocial interventions. While a partial improvement was observed, the case underscores the complexities of managing CS in the context of LBD, highlighting the need for tailored and multidisciplinary approaches to care. This case contributes to the limited literature on CS in LBD and provides practical insights for clinicians managing similar presentations.
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spelling doaj-art-03b4bc9bd1aa47b192e81f2845bf03912025-08-20T03:07:11ZengWileyCase Reports in Psychiatry2090-68382025-01-01202510.1155/crps/5541100Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary ManagementManuel Glauco Carbone0Tommaso Merati1Rossella Miccichè2Camilla Callegari3Beniamino Tripodi4Claudia Tagliarini5Icro Maremmani6Donatella Marazziti7Department of Medicine and SurgeryDepartment of Medicine and SurgeryDepartment of Medicine and SurgeryDepartment of Medicine and SurgeryDepartment of Mental Health and AddictionsDepartment of Mental HealthSaint Camillus International University of Health and Medical SciencesSaint Camillus International University of Health and Medical SciencesCapgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her deceased husband had been replaced by an imposter. The clinical presentation was complex, including pronounced sleep disturbances, cognitive decline, behavioral anomalies, and visual hallucinations, necessitating a thorough differential diagnosis process. We detail the patient’s history, clinical findings, and the investigations undertaken, including brain imaging and cognitive assessments. The management approach involved a personalized treatment plan integrating Lithium sulfate, Citalopram, and Lurasidone, alongside psychosocial interventions. While a partial improvement was observed, the case underscores the complexities of managing CS in the context of LBD, highlighting the need for tailored and multidisciplinary approaches to care. This case contributes to the limited literature on CS in LBD and provides practical insights for clinicians managing similar presentations.http://dx.doi.org/10.1155/crps/5541100
spellingShingle Manuel Glauco Carbone
Tommaso Merati
Rossella Miccichè
Camilla Callegari
Beniamino Tripodi
Claudia Tagliarini
Icro Maremmani
Donatella Marazziti
Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management
Case Reports in Psychiatry
title Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management
title_full Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management
title_fullStr Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management
title_full_unstemmed Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management
title_short Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management
title_sort beyond the imposter deciphering capgras syndrome and multidisciplinary management
url http://dx.doi.org/10.1155/crps/5541100
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