Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release
Poly(carboxylic acid)-polysaccharide compositions have been found suitable for obtaining drug formulations with controlled release, most formulations being therapeutically efficacious, stable, and non-irritant. The influence of the characteristics of the aqueous solutions from which the polymer matr...
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| Format: | Article |
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| Language: | English |
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Budapest University of Technology and Economics
2009-05-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0000911&mi=cd |
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| description | Poly(carboxylic acid)-polysaccharide compositions have been found suitable for obtaining drug formulations with controlled release, most formulations being therapeutically efficacious, stable, and non-irritant. The influence of the characteristics of the aqueous solutions from which the polymer matrix is prepared (i.e. the total concentration of polymer in solutions and the mixing ratio between the partners, hydroxypropyl cellulose, HPC and maleic acid-alternating-styrene copolymer, MAc-alt-S) on the kinetics of some drugs release in acidic environment (pH = 2) has been followed by ‘in vitro’ dissolution tests. It has been established that the kinetics of procaine hydrochloride release from HPC/MAc-alt-S matrix depends on its composition; the diffusion exponent, n is close to 0.5 for matrices where one of the components is in large excess and n~0.02 for middle composition range. The lower value of diffusion exponent for middle composition range could be caused by the so called ‘burst effect’, therefore the kinetic evaluation is difficult. |
| format | Article |
| id | doaj-art-03b052ceb869411f9864eb0d1f44a043 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2009-05-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-03b052ceb869411f9864eb0d1f44a0432025-08-20T03:32:33ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2009-05-013528629410.3144/expresspolymlett.2009.36Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug releasePoly(carboxylic acid)-polysaccharide compositions have been found suitable for obtaining drug formulations with controlled release, most formulations being therapeutically efficacious, stable, and non-irritant. The influence of the characteristics of the aqueous solutions from which the polymer matrix is prepared (i.e. the total concentration of polymer in solutions and the mixing ratio between the partners, hydroxypropyl cellulose, HPC and maleic acid-alternating-styrene copolymer, MAc-alt-S) on the kinetics of some drugs release in acidic environment (pH = 2) has been followed by ‘in vitro’ dissolution tests. It has been established that the kinetics of procaine hydrochloride release from HPC/MAc-alt-S matrix depends on its composition; the diffusion exponent, n is close to 0.5 for matrices where one of the components is in large excess and n~0.02 for middle composition range. The lower value of diffusion exponent for middle composition range could be caused by the so called ‘burst effect’, therefore the kinetic evaluation is difficult.http://www.expresspolymlett.com/letolt.php?file=EPL-0000911&mi=cdBiocompatible polymersinterpolymeric associationhydroxypropyl cellulosemaleic copolymerdrug release |
| spellingShingle | Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release eXPRESS Polymer Letters Biocompatible polymers interpolymeric association hydroxypropyl cellulose maleic copolymer drug release |
| title | Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release |
| title_full | Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release |
| title_fullStr | Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release |
| title_full_unstemmed | Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release |
| title_short | Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release |
| title_sort | influence of the composition of hydroxypropyl cellulose maleic acid alt styrene copolymer blends on their properties as matrix for drug release |
| topic | Biocompatible polymers interpolymeric association hydroxypropyl cellulose maleic copolymer drug release |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0000911&mi=cd |