Sex- and age-dependent neurovascular abnormalities linked to neuroinflammation lead to exacerbated post-ischemic brain injury in Marfan syndrome mice

Sex- and age-dependent neurovascular abnormalities linked to neuroinflammation lead to exacerbated post-ischemic brain injury in Marfan syndrome mice

Fibrillin 1 gene (Fbn1) mutations cause Marfan syndrome (MFS), triggering life-threatening aortic complications and multi-organ effects. MFS is increasingly linked to neurovascular complications, amplified by aortic surgery risks. However, the impact of MFS on the brain remains unclear, including th...

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Main Authors: Gemma Manich, Belén Pérez, Clara Penas, Ana Paula Dantas, Joana Coutinho, Paula Sánchez-Bernadó, Julián García-Aranda, Juan Fraile-Ramos, Núria Benseny-Cases, Beatriz Martín-Mur, Anna Esteve-Codina, Isaac Rodríguez-Rovira, Lydia Giménez-Llort, Gustavo Egea, Francesc Jiménez-Altayó
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
Marfan syndrome
fibrillin 1
Neurovascular complications
Ischemic brain injury
Neuroinflammation
Extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001752
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