Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis
Late graft thrombosis is an infrequent yet severe complication post renal transplantation, profoundly affecting graft survival and patient prognosis. We report a case of a 29-year-old male with end-stage renal disease due to IgA nephropathy who underwent ABO-incompatible renal transplantation. Despi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Transplantation |
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| Online Access: | https://journals.lww.com/10.4103/ijot.ijot_61_24 |
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| author | Abhishek Pratap Singh Pankaj Beniwal Vinay Malhotra |
| author_facet | Abhishek Pratap Singh Pankaj Beniwal Vinay Malhotra |
| author_sort | Abhishek Pratap Singh |
| collection | DOAJ |
| description | Late graft thrombosis is an infrequent yet severe complication post renal transplantation, profoundly affecting graft survival and patient prognosis. We report a case of a 29-year-old male with end-stage renal disease due to IgA nephropathy who underwent ABO-incompatible renal transplantation. Despite effective desensitization, the patient experienced late graft thrombosis 3 months posttransplant, resulting in irreversible graft failure and necessitating hemodialysis initiation. This case underscores the complexities of late graft thrombosis and emphasizes the significance of timely identification and intervention for optimizing transplant outcomes. |
| format | Article |
| id | doaj-art-03ade2fcda744a84928841e2deb11b34 |
| institution | Kabale University |
| issn | 2212-0017 2212-0025 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj-art-03ade2fcda744a84928841e2deb11b342025-01-07T06:12:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252024-12-0118447247510.4103/ijot.ijot_61_24Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft ThrombosisAbhishek Pratap SinghPankaj BeniwalVinay MalhotraLate graft thrombosis is an infrequent yet severe complication post renal transplantation, profoundly affecting graft survival and patient prognosis. We report a case of a 29-year-old male with end-stage renal disease due to IgA nephropathy who underwent ABO-incompatible renal transplantation. Despite effective desensitization, the patient experienced late graft thrombosis 3 months posttransplant, resulting in irreversible graft failure and necessitating hemodialysis initiation. This case underscores the complexities of late graft thrombosis and emphasizes the significance of timely identification and intervention for optimizing transplant outcomes.https://journals.lww.com/10.4103/ijot.ijot_61_24abo-incompatible transplantationantibody-mediated rejectiondesensitizationgraft losshigh-risk transplant scenariosimmunosuppressionrenal allograft thrombosisrenal transplantation complicationsthrombotic microangiopathytreatment challenges |
| spellingShingle | Abhishek Pratap Singh Pankaj Beniwal Vinay Malhotra Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis Indian Journal of Transplantation abo-incompatible transplantation antibody-mediated rejection desensitization graft loss high-risk transplant scenarios immunosuppression renal allograft thrombosis renal transplantation complications thrombotic microangiopathy treatment challenges |
| title | Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis |
| title_full | Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis |
| title_fullStr | Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis |
| title_full_unstemmed | Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis |
| title_short | Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis |
| title_sort | challenges in abo incompatible renal transplantation a case report of acute antibody mediated rejection with late graft thrombosis |
| topic | abo-incompatible transplantation antibody-mediated rejection desensitization graft loss high-risk transplant scenarios immunosuppression renal allograft thrombosis renal transplantation complications thrombotic microangiopathy treatment challenges |
| url | https://journals.lww.com/10.4103/ijot.ijot_61_24 |
| work_keys_str_mv | AT abhishekpratapsingh challengesinaboincompatiblerenaltransplantationacasereportofacuteantibodymediatedrejectionwithlategraftthrombosis AT pankajbeniwal challengesinaboincompatiblerenaltransplantationacasereportofacuteantibodymediatedrejectionwithlategraftthrombosis AT vinaymalhotra challengesinaboincompatiblerenaltransplantationacasereportofacuteantibodymediatedrejectionwithlategraftthrombosis |