Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs
Bladder cancer (BC) is a malignant tumor characterized by a high incidence of urinary system diseases. The complex pathogenesis of BC has long been a focal point in medical research. With the robust development of epigenetics, the crucial role of epigenetic modifications in the occurrence and progre...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518144/full |
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| author | Wei Li Wei Li Wei Li Peiyue Luo Peiyue Luo Peiyue Luo Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Lifeng Gan Lifeng Gan Lifeng Gan Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Liying Zheng Biao Qian Biao Qian |
| author_facet | Wei Li Wei Li Wei Li Peiyue Luo Peiyue Luo Peiyue Luo Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Lifeng Gan Lifeng Gan Lifeng Gan Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Liying Zheng Biao Qian Biao Qian |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Bladder cancer (BC) is a malignant tumor characterized by a high incidence of urinary system diseases. The complex pathogenesis of BC has long been a focal point in medical research. With the robust development of epigenetics, the crucial role of epigenetic modifications in the occurrence and progression of BC has been elucidated. These modifications not only affect gene expression but also impact critical biological behaviors of tumor cells, including proliferation, differentiation, apoptosis, invasion, and metastasis. Notably, DNA methylation, an important epigenetic regulatory mechanism, often manifests as global hypomethylation or hypermethylation of specific gene promoter regions in BC. Alterations in this methylation pattern can lead to increased genomic instability, which profoundly influences the expression of proto-oncogenes and tumor suppressor genes. MiRNAs, as noncoding small RNAs, participate in various biological processes of BC by regulating target genes. Consequently, this work aims to explore the interaction mechanisms between DNA methylation and miRNAs in the occurrence and development of BC. Research has demonstrated that DNA methylation not only directly influences the expression of miRNA genes but also indirectly affects the maturation and functionality of miRNAs by modulating the methylation status of miRNA promoter regions. Simultaneously, miRNAs can regulate DNA methylation levels by targeting key enzymes such as DNA methyltransferases (DNMTs), thereby establishing a complex feedback regulatory network. A deeper understanding of the crosstalk mechanisms between DNA methylation and miRNAs in BC will contribute to elucidating the complexity and dynamics of epigenetic modifications in this disease, and may provide new molecular targets and strategies for the early diagnosis, treatment, and prognostic evaluation of BC. |
| format | Article |
| id | doaj-art-03aa1fbe46d64322b17bfdd1ca5cb0c6 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-03aa1fbe46d64322b17bfdd1ca5cb0c62025-02-05T07:32:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15181441518144Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAsWei Li0Wei Li1Wei Li2Peiyue Luo3Peiyue Luo4Peiyue Luo5Qi Chen6Qi Chen7Qi Chen8Le Cheng9Le Cheng10Le Cheng11Lifeng Gan12Lifeng Gan13Lifeng Gan14Fangtao Zhang15Fangtao Zhang16Fangtao Zhang17Haidong Zhong18Haidong Zhong19Haidong Zhong20Liying Zheng21Biao Qian22Biao Qian23The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Graduate, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaBladder cancer (BC) is a malignant tumor characterized by a high incidence of urinary system diseases. The complex pathogenesis of BC has long been a focal point in medical research. With the robust development of epigenetics, the crucial role of epigenetic modifications in the occurrence and progression of BC has been elucidated. These modifications not only affect gene expression but also impact critical biological behaviors of tumor cells, including proliferation, differentiation, apoptosis, invasion, and metastasis. Notably, DNA methylation, an important epigenetic regulatory mechanism, often manifests as global hypomethylation or hypermethylation of specific gene promoter regions in BC. Alterations in this methylation pattern can lead to increased genomic instability, which profoundly influences the expression of proto-oncogenes and tumor suppressor genes. MiRNAs, as noncoding small RNAs, participate in various biological processes of BC by regulating target genes. Consequently, this work aims to explore the interaction mechanisms between DNA methylation and miRNAs in the occurrence and development of BC. Research has demonstrated that DNA methylation not only directly influences the expression of miRNA genes but also indirectly affects the maturation and functionality of miRNAs by modulating the methylation status of miRNA promoter regions. Simultaneously, miRNAs can regulate DNA methylation levels by targeting key enzymes such as DNA methyltransferases (DNMTs), thereby establishing a complex feedback regulatory network. A deeper understanding of the crosstalk mechanisms between DNA methylation and miRNAs in BC will contribute to elucidating the complexity and dynamics of epigenetic modifications in this disease, and may provide new molecular targets and strategies for the early diagnosis, treatment, and prognostic evaluation of BC.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518144/fullbladder cancerepigenetic modificationDNA methylationmicroRNAcancer therapy |
| spellingShingle | Wei Li Wei Li Wei Li Peiyue Luo Peiyue Luo Peiyue Luo Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Lifeng Gan Lifeng Gan Lifeng Gan Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Liying Zheng Biao Qian Biao Qian Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs Frontiers in Immunology bladder cancer epigenetic modification DNA methylation microRNA cancer therapy |
| title | Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs |
| title_full | Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs |
| title_fullStr | Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs |
| title_full_unstemmed | Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs |
| title_short | Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs |
| title_sort | epigenetic modifications in bladder cancer crosstalk between dna methylation and mirnas |
| topic | bladder cancer epigenetic modification DNA methylation microRNA cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518144/full |
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