Anti-tumor effects of metformin in animal models of hepatocellular carcinoma: a systematic review and meta-analysis.
<h4>Background</h4>Several studies have reported that metformin can reduce the risk of hepatocellular carcinoma (HCC) in diabetes patients. However, the direct anti-HCC effects of metformin have hardly been studied in patients, but have been extensively investigated in animal models of H...
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| Main Authors: | Juan Li, Pratika Y Hernanda, Wichor M Bramer, Maikel P Peppelenbosch, Judith van Luijk, Qiuwei Pan |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0127967 |
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