Efficacy of a dietary supplement on the molecular and clinical parameters of skin aging
INTRODUCTION: Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense, seems to be the main process that worsens skin aging, and the mitochondria is an important source of ROS. There is increasing evidence that oral administrati...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia (SBD)
2025-03-01
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| Series: | Surgical & Cosmetic Dermatology |
| Subjects: | |
| Online Access: | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250308.pdf |
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| Summary: | INTRODUCTION: Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense, seems to be the main process that worsens skin aging, and the mitochondria is an important source of ROS. There is increasing evidence that oral administration of functional nutrients can protect the skin from oxidative damage.
OBJECTIVE: To evaluate the effectiveness of an oral supplement with collagen peptides and other nutrients in reducing the signs of photoaging.
METHODS: In vitro studies evaluated the antioxidant and antiglycant effects under UV light, as well as the synthesis of extracellular dermal matrix components; then, a clinical trial was developed with women between 35 and 60 years old, for 12 weeks. Hydration (corneometry) and skin firmness (cutometry) measurements were performed.
RESULTS: The supplement showed antioxidant and antiglycant properties under the stress generated by UV radiation, as well as the ability to induce synthesis of extracellular dermal matrix elements; There was an improvement in all clinical parameters of aging. Significant improvement in hydration and firmness and elasticity were also observed.
CONCLUSION: Collagen peptides and nutrients association demonstrated an effect in some mechanisms involved in the photoaging process, leading a clinical improvement. |
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| ISSN: | 1984-8773 |