<i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production
<i>Pseudomonas aeruginosa</i> is a metabolically versatile opportunistic pathogen capable of surviving in a range of environments. The major contribution to these abilities relies on virulence factor production, e.g., exotoxins, phenazines, and rhamnolipids, regulated through a hierarchi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/4/4/47 |
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| author | Doumit Camilios-Neto Rodolfo Ricken do Nascimento Jonathan Ratko Nicole Caldas Pan Rubia Casagrande Waldiceu A. Verri Josiane A. Vignoli |
| author_facet | Doumit Camilios-Neto Rodolfo Ricken do Nascimento Jonathan Ratko Nicole Caldas Pan Rubia Casagrande Waldiceu A. Verri Josiane A. Vignoli |
| author_sort | Doumit Camilios-Neto |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> is a metabolically versatile opportunistic pathogen capable of surviving in a range of environments. The major contribution to these abilities relies on virulence factor production, e.g., exotoxins, phenazines, and rhamnolipids, regulated through a hierarchical system of communication, named quorum sensing (QS). QS involves the production, release, and recognition of two classes of diffusible signal molecules: N-acyl-homoserine lactones and alkyl-quinolones. These present a central role during <i>P. aeruginosa</i> infection, regulating bacterial virulence and the modulation of the host immune system. The influence of this arsenal of virulence factors on bacterial–host interaction makes <i>P. aeruginosa</i> a highly potential platform for the development of biopharmaceuticals. Here, we comprehensively reviewed the therapeutical applications of <i>P. aeruginosa</i> virulence factors and quorum sensing signaling molecules on pathological conditions, ranging from infections and inflammation to cancer disease. |
| format | Article |
| id | doaj-art-03a0252b336d4d65bed28ddb7d588ffc |
| institution | DOAJ |
| issn | 2673-9879 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj-art-03a0252b336d4d65bed28ddb7d588ffc2025-08-20T02:55:38ZengMDPI AGFuture Pharmacology2673-98792024-12-014489291810.3390/futurepharmacol4040047<i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical ProductionDoumit Camilios-Neto0Rodolfo Ricken do Nascimento1Jonathan Ratko2Nicole Caldas Pan3Rubia Casagrande4Waldiceu A. Verri5Josiane A. Vignoli6Departamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina 86057-970, BrazilDepartamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina 86057-970, BrazilDepartamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina 86057-970, BrazilDepartamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina 86057-970, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Londrina 86057-970, BrazilDepartamento de Imunologia, Parasitologia e Patologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina 86057-970, BrazilDepartamento de Bioquímica e Biotecnologia, Centro de Ciências Exatas, Universidade Estadual de Londrina, Londrina 86057-970, Brazil<i>Pseudomonas aeruginosa</i> is a metabolically versatile opportunistic pathogen capable of surviving in a range of environments. The major contribution to these abilities relies on virulence factor production, e.g., exotoxins, phenazines, and rhamnolipids, regulated through a hierarchical system of communication, named quorum sensing (QS). QS involves the production, release, and recognition of two classes of diffusible signal molecules: N-acyl-homoserine lactones and alkyl-quinolones. These present a central role during <i>P. aeruginosa</i> infection, regulating bacterial virulence and the modulation of the host immune system. The influence of this arsenal of virulence factors on bacterial–host interaction makes <i>P. aeruginosa</i> a highly potential platform for the development of biopharmaceuticals. Here, we comprehensively reviewed the therapeutical applications of <i>P. aeruginosa</i> virulence factors and quorum sensing signaling molecules on pathological conditions, ranging from infections and inflammation to cancer disease.https://www.mdpi.com/2673-9879/4/4/47rhamnolipidsphenazinesquorum sensingvirulence factorsbiological drugs |
| spellingShingle | Doumit Camilios-Neto Rodolfo Ricken do Nascimento Jonathan Ratko Nicole Caldas Pan Rubia Casagrande Waldiceu A. Verri Josiane A. Vignoli <i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production Future Pharmacology rhamnolipids phenazines quorum sensing virulence factors biological drugs |
| title | <i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production |
| title_full | <i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production |
| title_fullStr | <i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production |
| title_full_unstemmed | <i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production |
| title_short | <i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production |
| title_sort | i pseudomonas aeruginosa i a bacterial platform for biopharmaceutical production |
| topic | rhamnolipids phenazines quorum sensing virulence factors biological drugs |
| url | https://www.mdpi.com/2673-9879/4/4/47 |
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