<i>Pseudomonas aeruginosa</i>: A Bacterial Platform for Biopharmaceutical Production
<i>Pseudomonas aeruginosa</i> is a metabolically versatile opportunistic pathogen capable of surviving in a range of environments. The major contribution to these abilities relies on virulence factor production, e.g., exotoxins, phenazines, and rhamnolipids, regulated through a hierarchi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Future Pharmacology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9879/4/4/47 |
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| Summary: | <i>Pseudomonas aeruginosa</i> is a metabolically versatile opportunistic pathogen capable of surviving in a range of environments. The major contribution to these abilities relies on virulence factor production, e.g., exotoxins, phenazines, and rhamnolipids, regulated through a hierarchical system of communication, named quorum sensing (QS). QS involves the production, release, and recognition of two classes of diffusible signal molecules: N-acyl-homoserine lactones and alkyl-quinolones. These present a central role during <i>P. aeruginosa</i> infection, regulating bacterial virulence and the modulation of the host immune system. The influence of this arsenal of virulence factors on bacterial–host interaction makes <i>P. aeruginosa</i> a highly potential platform for the development of biopharmaceuticals. Here, we comprehensively reviewed the therapeutical applications of <i>P. aeruginosa</i> virulence factors and quorum sensing signaling molecules on pathological conditions, ranging from infections and inflammation to cancer disease. |
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| ISSN: | 2673-9879 |