Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim
This search reports the synthesis of some new series of Schiff base compounds for trimetheprim derivatives which known high been known as a medicinal effectiveness. Trimetheprim was condensed with several substituted aldehydes compounds.(4-dimethyl amine benzaldehyde , propanal , salicaldehyde, 2.4...
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Science for Women
2010-03-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2905 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | This search reports the synthesis of some new series of Schiff base compounds for trimetheprim derivatives which known high been known as a medicinal effectiveness. Trimetheprim was condensed with several substituted aldehydes compounds.(4-dimethyl amine benzaldehyde , propanal , salicaldehyde, 2.4 dimethoxy benzaldehyde and 4- methyl benzaldehyde) to obtain Schiff base products(1a-5a) and several substituted ketones compound (4-aminoacetophenone,4-chloroacetophenone, isobutyleketone, acetylacetone and acetophenone) to obtain Schiff base products(6b-10b) in ethanol in the presence of concentrated sulphuric acid as a catalyst to yield the Schiff base. The structure of synthesized compounds has been established on the basis of their Chemical structures of all products were confirmed by spectrophotometric methods such as U.V. visible and FTIR.. All these compounds were evaluated for their antibacterial activity in vitro against Gram + ve bacteria (bacillus) , Gram –ve bacteria (E-Coli).Most Compound under investigation exhibited potent antibacterial activity |
| format | Article |
| id | doaj-art-0398e6bfbd0a453b9f5e90ab0d4a8522 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2010-03-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-0398e6bfbd0a453b9f5e90ab0d4a85222025-08-20T03:58:10ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862010-03-017110.21123/bsj.7.1.614-620Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for TrimethoprimBaghdad Science JournalThis search reports the synthesis of some new series of Schiff base compounds for trimetheprim derivatives which known high been known as a medicinal effectiveness. Trimetheprim was condensed with several substituted aldehydes compounds.(4-dimethyl amine benzaldehyde , propanal , salicaldehyde, 2.4 dimethoxy benzaldehyde and 4- methyl benzaldehyde) to obtain Schiff base products(1a-5a) and several substituted ketones compound (4-aminoacetophenone,4-chloroacetophenone, isobutyleketone, acetylacetone and acetophenone) to obtain Schiff base products(6b-10b) in ethanol in the presence of concentrated sulphuric acid as a catalyst to yield the Schiff base. The structure of synthesized compounds has been established on the basis of their Chemical structures of all products were confirmed by spectrophotometric methods such as U.V. visible and FTIR.. All these compounds were evaluated for their antibacterial activity in vitro against Gram + ve bacteria (bacillus) , Gram –ve bacteria (E-Coli).Most Compound under investigation exhibited potent antibacterial activityhttp://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2905"Ttrimetheprim , Schiff bases , aldehyde .ketone, antibacterial activity." |
| spellingShingle | Baghdad Science Journal Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim مجلة بغداد للعلوم "Ttrimetheprim , Schiff bases , aldehyde .ketone, antibacterial activity." |
| title | Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim |
| title_full | Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim |
| title_fullStr | Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim |
| title_full_unstemmed | Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim |
| title_short | Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim |
| title_sort | synthesis characterization and antimicrobial activity study via some new schiff bases for trimethoprim |
| topic | "Ttrimetheprim , Schiff bases , aldehyde .ketone, antibacterial activity." |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2905 |
| work_keys_str_mv | AT baghdadsciencejournal synthesischaracterizationandantimicrobialactivitystudyviasomenewschiffbasesfortrimethoprim |