Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review
Background: Osteoarthritis is a common chronic disease that affects quality of life and increases public health costs. Knee osteoarthritis is a frequent form, marked by joint degeneration, pain, stiffness, and functional restrictions. Factors such as age, genetics, joint injuries, obesity, and vitam...
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MDPI AG
2024-09-01
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| Online Access: | https://www.mdpi.com/2039-7283/14/5/158 |
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| author | Bianca Georgescu Adelina Elena Cristea Doinița Oprea Andreea Alexandra Lupu Liliana-Elena Stanciu Erdin Borgazi Bogdan Marian Caraban Viorela Mihaela Ciortea Laszlo Irsay Mădălina Gabriela Iliescu |
| author_facet | Bianca Georgescu Adelina Elena Cristea Doinița Oprea Andreea Alexandra Lupu Liliana-Elena Stanciu Erdin Borgazi Bogdan Marian Caraban Viorela Mihaela Ciortea Laszlo Irsay Mădălina Gabriela Iliescu |
| author_sort | Bianca Georgescu |
| collection | DOAJ |
| description | Background: Osteoarthritis is a common chronic disease that affects quality of life and increases public health costs. Knee osteoarthritis is a frequent form, marked by joint degeneration, pain, stiffness, and functional restrictions. Factors such as age, genetics, joint injuries, obesity, and vitamin D deficiency can affect knee osteoarthritis progression. While the exact link between vitamin D and osteoarthritis is still being studied, recent research indicates that low vitamin D levels might influence the articular cartilage’s structure and function, potentially accelerating osteoarthritis. This review aims to analyze the last decade of research on vitamin D’s role in osteoarthritis. Methods: A systematic review of the literature was conducted in accordance with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Relevant studies from the last ten years were included to evaluate the association between vitamin D levels and knee osteoarthritis. The inclusion criteria were studies examining the role of vitamin D in cartilage health and osteoarthritis progression and the potential clinical implications for disease management. Results: This review identified a variety of studies exploring the connection between vitamin D and osteoarthritis, with mixed findings. Conclusions: The relationship between vitamin D and knee osteoarthritis remains inconclusive, highlighting the need for further research. An updated evaluation of the literature is crucial for osteoarthritis management strategies and to potentially include vitamin D supplementation in therapeutic protocols. |
| format | Article |
| id | doaj-art-0397a1c3d57a48b882687a2d2b64e956 |
| institution | OA Journals |
| issn | 2039-7283 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj-art-0397a1c3d57a48b882687a2d2b64e9562025-08-20T02:11:05ZengMDPI AGClinics and Practice2039-72832024-09-011451997201210.3390/clinpract14050158Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic ReviewBianca Georgescu0Adelina Elena Cristea1Doinița Oprea2Andreea Alexandra Lupu3Liliana-Elena Stanciu4Erdin Borgazi5Bogdan Marian Caraban6Viorela Mihaela Ciortea7Laszlo Irsay8Mădălina Gabriela Iliescu9Medical Doctoral School, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaMedical Doctoral School, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaDepartment of Physical Medicine and Rehabilitation, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaDepartment of Orthopedics, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaDepartment of Plastic Surgery, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaDepartment of Rehabilitation Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, 8 Victor Babes Street, 400012 Cluj-Napoca, RomaniaDepartment of Rehabilitation Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, 8 Victor Babes Street, 400012 Cluj-Napoca, RomaniaMedical Doctoral School, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus—Corp B, 900470 Constanta, RomaniaBackground: Osteoarthritis is a common chronic disease that affects quality of life and increases public health costs. Knee osteoarthritis is a frequent form, marked by joint degeneration, pain, stiffness, and functional restrictions. Factors such as age, genetics, joint injuries, obesity, and vitamin D deficiency can affect knee osteoarthritis progression. While the exact link between vitamin D and osteoarthritis is still being studied, recent research indicates that low vitamin D levels might influence the articular cartilage’s structure and function, potentially accelerating osteoarthritis. This review aims to analyze the last decade of research on vitamin D’s role in osteoarthritis. Methods: A systematic review of the literature was conducted in accordance with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Relevant studies from the last ten years were included to evaluate the association between vitamin D levels and knee osteoarthritis. The inclusion criteria were studies examining the role of vitamin D in cartilage health and osteoarthritis progression and the potential clinical implications for disease management. Results: This review identified a variety of studies exploring the connection between vitamin D and osteoarthritis, with mixed findings. Conclusions: The relationship between vitamin D and knee osteoarthritis remains inconclusive, highlighting the need for further research. An updated evaluation of the literature is crucial for osteoarthritis management strategies and to potentially include vitamin D supplementation in therapeutic protocols.https://www.mdpi.com/2039-7283/14/5/158knee osteoarthritisvitamin D deficiencymedical rehabilitation |
| spellingShingle | Bianca Georgescu Adelina Elena Cristea Doinița Oprea Andreea Alexandra Lupu Liliana-Elena Stanciu Erdin Borgazi Bogdan Marian Caraban Viorela Mihaela Ciortea Laszlo Irsay Mădălina Gabriela Iliescu Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review Clinics and Practice knee osteoarthritis vitamin D deficiency medical rehabilitation |
| title | Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review |
| title_full | Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review |
| title_fullStr | Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review |
| title_full_unstemmed | Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review |
| title_short | Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review |
| title_sort | current evidence on and clinical implications of vitamin d levels in pain and functional management of knee osteoarthritis a systematic review |
| topic | knee osteoarthritis vitamin D deficiency medical rehabilitation |
| url | https://www.mdpi.com/2039-7283/14/5/158 |
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