Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release

Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release

Abstract Background Sepsis is a life-threatening condition that often leads to severe complications, including acute lung injury (ALI), which carries high morbidity and mortality in critically ill patients. Melatonin (Mel) has shown significant protective effects against sepsis-induced ALI, but its...

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Bibliographic Details
Main Authors: Yuce Peng, Jia Xu, Lingyu Wei, Minghao Luo, Shenglong Chen, Xuebiao Wei, Suxin Luo, Zedazhong Su, Zhonghua Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Melatonin
Sepsis
ALI
Necroptosis
mtDNA-STING
Online Access:https://doi.org/10.1186/s10020-025-01228-z
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