Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer
Abstract The left ventricular trabecular fractal dimension (LVTFD) derived from cardiac magnetic resonance reflects myocardial trabecular complexity, which is associated with cardiovascular disease risk. Baseline risk stratification of cancer therapy–related cardiac dysfunction (CTRCD) in patients w...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.70004 |
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| author | Hesong Shen Qian Xu Chunrong Tu Yangling Peng Yuhang Xie Zhiming Miao Rui Yang Jiuquan Zhang |
| author_facet | Hesong Shen Qian Xu Chunrong Tu Yangling Peng Yuhang Xie Zhiming Miao Rui Yang Jiuquan Zhang |
| author_sort | Hesong Shen |
| collection | DOAJ |
| description | Abstract The left ventricular trabecular fractal dimension (LVTFD) derived from cardiac magnetic resonance reflects myocardial trabecular complexity, which is associated with cardiovascular disease risk. Baseline risk stratification of cancer therapy–related cardiac dysfunction (CTRCD) in patients with breast cancer who received anthracycline is a very important clinical issue. In this study, we used the Cox model to derive and validate a new score system based on LVTFD for baseline risk stratification of CTRCD in breast cancer patients receiving anthracycline. We also compare the performance of LVTFD‐based score with the Heart Failure Association‐International Cardio‐Oncology Society (HFA‐ICOS) score using C‐index. This study enrolled 370 participants, of whom 73 participants developed CTRCD. The C‐indices of LVTFD‐based score integrating age, hypertension, previous cardiovascular disease, and maximal apical fractal dimension were higher than those of HFA‐ICOS score for stratifying CTRCD (0.834 vs. 0.642 and 0.834 vs. 0.633, respectively, in derivation and validation cohort). LVTFD‐based score can stratify the CTRCD risk, but HFA‐ICOS score cannot. The above results reveal that the LVTFD‐based score is an alternative method for baseline risk stratification of CTRCD in breast cancer who received anthracycline. |
| format | Article |
| id | doaj-art-0392bdb9f6404395acc60ba3bb83f5e7 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-0392bdb9f6404395acc60ba3bb83f5e72025-01-20T01:45:44ZengWileyMedComm2688-26632025-01-0161n/an/a10.1002/mco2.70004Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancerHesong Shen0Qian Xu1Chunrong Tu2Yangling Peng3Yuhang Xie4Zhiming Miao5Rui Yang6Jiuquan Zhang7Department of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaSchool of Medicine Chongqing University Chongqing ChinaDepartment of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaDepartment of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaDepartment of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaDepartment of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaDepartment of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaDepartment of Radiology Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital Chongqing ChinaAbstract The left ventricular trabecular fractal dimension (LVTFD) derived from cardiac magnetic resonance reflects myocardial trabecular complexity, which is associated with cardiovascular disease risk. Baseline risk stratification of cancer therapy–related cardiac dysfunction (CTRCD) in patients with breast cancer who received anthracycline is a very important clinical issue. In this study, we used the Cox model to derive and validate a new score system based on LVTFD for baseline risk stratification of CTRCD in breast cancer patients receiving anthracycline. We also compare the performance of LVTFD‐based score with the Heart Failure Association‐International Cardio‐Oncology Society (HFA‐ICOS) score using C‐index. This study enrolled 370 participants, of whom 73 participants developed CTRCD. The C‐indices of LVTFD‐based score integrating age, hypertension, previous cardiovascular disease, and maximal apical fractal dimension were higher than those of HFA‐ICOS score for stratifying CTRCD (0.834 vs. 0.642 and 0.834 vs. 0.633, respectively, in derivation and validation cohort). LVTFD‐based score can stratify the CTRCD risk, but HFA‐ICOS score cannot. The above results reveal that the LVTFD‐based score is an alternative method for baseline risk stratification of CTRCD in breast cancer who received anthracycline.https://doi.org/10.1002/mco2.70004breast cancercardiotoxicitymagnetic resonance imaging |
| spellingShingle | Hesong Shen Qian Xu Chunrong Tu Yangling Peng Yuhang Xie Zhiming Miao Rui Yang Jiuquan Zhang Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer MedComm breast cancer cardiotoxicity magnetic resonance imaging |
| title | Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer |
| title_full | Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer |
| title_fullStr | Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer |
| title_full_unstemmed | Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer |
| title_short | Left ventricular trabecular complexity for risk stratification of cancer therapy–related cardiac dysfunction in breast cancer |
| title_sort | left ventricular trabecular complexity for risk stratification of cancer therapy related cardiac dysfunction in breast cancer |
| topic | breast cancer cardiotoxicity magnetic resonance imaging |
| url | https://doi.org/10.1002/mco2.70004 |
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