Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis
Objective To investigate the clinical significance of serum and urinary neutrophil gelatinase associated lipocalin(NGAL)for early prediction of acute kidney injury(AKI)following severe acute pancreatitis(SAP).Methods A total of 145 cases of acute pancreatitis who were hospitalized in Hunan Provincia...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2018-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57915854&Fpath=home&index=0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849729439966953472 |
|---|---|
| author | CHEN Yan-hong WU Yan-hong YU Hai-ming PEI Xing-hua HUANG li ZHOU Xu |
| author_facet | CHEN Yan-hong WU Yan-hong YU Hai-ming PEI Xing-hua HUANG li ZHOU Xu |
| author_sort | CHEN Yan-hong |
| collection | DOAJ |
| description | Objective To investigate the clinical significance of serum and urinary neutrophil gelatinase associated lipocalin(NGAL)for early prediction of acute kidney injury(AKI)following severe acute pancreatitis(SAP).Methods A total of 145 cases of acute pancreatitis who were hospitalized in Hunan Provincial People’s Hospital from June 2013 to December 2015 were selected and divided into the mild acute pancreatitis(MAP)group(57 cases),SAP with AKI group(43 cases),and SAP with non-AKI group(45 cases),meanwhile 20 healthy volunteers from Physical Examination Center were selected as control group.The NGAL levels in serum and urine of all subjects were determined by ELISA and statistical analysis was performed.Results Compared with control group,the serum and urinary NGAL levels in MAP group,AKI group,and non-AKI group were significantly increased(P <0.01).The serum and urinary NGAL levels in AKI group and non-AKI group were higher than those of MAP group(P <0.01),but the NGAL levels were no significant difference between AKI group and non-AKI group(P>0.05).Conclusions The serum and urinary NGAL levels in patients with pancreatitis were significantly elevated and associated with the severity of pancreatitis,however it could not be used as an early marker of SAP with AKI. |
| format | Article |
| id | doaj-art-039222ed90694f14817ac7531dfd6eb2 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2018-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-039222ed90694f14817ac7531dfd6eb22025-08-20T03:09:13ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902018-01-0128128457915854Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitisCHEN Yan-hongWU Yan-hongYU Hai-mingPEI Xing-huaHUANG liZHOU XuObjective To investigate the clinical significance of serum and urinary neutrophil gelatinase associated lipocalin(NGAL)for early prediction of acute kidney injury(AKI)following severe acute pancreatitis(SAP).Methods A total of 145 cases of acute pancreatitis who were hospitalized in Hunan Provincial People’s Hospital from June 2013 to December 2015 were selected and divided into the mild acute pancreatitis(MAP)group(57 cases),SAP with AKI group(43 cases),and SAP with non-AKI group(45 cases),meanwhile 20 healthy volunteers from Physical Examination Center were selected as control group.The NGAL levels in serum and urine of all subjects were determined by ELISA and statistical analysis was performed.Results Compared with control group,the serum and urinary NGAL levels in MAP group,AKI group,and non-AKI group were significantly increased(P <0.01).The serum and urinary NGAL levels in AKI group and non-AKI group were higher than those of MAP group(P <0.01),but the NGAL levels were no significant difference between AKI group and non-AKI group(P>0.05).Conclusions The serum and urinary NGAL levels in patients with pancreatitis were significantly elevated and associated with the severity of pancreatitis,however it could not be used as an early marker of SAP with AKI.http://www.lcszb.com/thesisDetails?columnId=57915854&Fpath=home&index=0Severe acute pancreatitisNeutrophil gelatinase associated lipocalinAcute kidney injury |
| spellingShingle | CHEN Yan-hong WU Yan-hong YU Hai-ming PEI Xing-hua HUANG li ZHOU Xu Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis Linchuang shenzangbing zazhi Severe acute pancreatitis Neutrophil gelatinase associated lipocalin Acute kidney injury |
| title | Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis |
| title_full | Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis |
| title_fullStr | Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis |
| title_full_unstemmed | Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis |
| title_short | Neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis |
| title_sort | neutrophil gelatinase associated lipocalin in prediction of acute kidney injury following severe acute pancreatitis |
| topic | Severe acute pancreatitis Neutrophil gelatinase associated lipocalin Acute kidney injury |
| url | http://www.lcszb.com/thesisDetails?columnId=57915854&Fpath=home&index=0 |
| work_keys_str_mv | AT chenyanhong neutrophilgelatinaseassociatedlipocalininpredictionofacutekidneyinjuryfollowingsevereacutepancreatitis AT wuyanhong neutrophilgelatinaseassociatedlipocalininpredictionofacutekidneyinjuryfollowingsevereacutepancreatitis AT yuhaiming neutrophilgelatinaseassociatedlipocalininpredictionofacutekidneyinjuryfollowingsevereacutepancreatitis AT peixinghua neutrophilgelatinaseassociatedlipocalininpredictionofacutekidneyinjuryfollowingsevereacutepancreatitis AT huangli neutrophilgelatinaseassociatedlipocalininpredictionofacutekidneyinjuryfollowingsevereacutepancreatitis AT zhouxu neutrophilgelatinaseassociatedlipocalininpredictionofacutekidneyinjuryfollowingsevereacutepancreatitis |