Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis

Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis

Abstract Background Immune checkpoint inhibitors (ICI) and chemotherapy, including antibody-drug conjugates, are widely used for the treatment of patients with advanced unresectable or metastatic urothelial carcinoma (UC). The majority of elderly patients receive concomitant medications to address v...

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Main Authors: Ichiro Tsuboi, Akihiro Matsukawa, Mehdi Kardoust Parizi, Marcin Miszczyk, Tamás Fazekas, Robert J Schulz, Ekaterina Laukhtina, Tatsushi Kawada, Satoshi Katayama, Takehiro Iwata, Kensuke Bekku, Pawel Rajwa, Koichiro Wada, Katharina Oberneder, Piotr Chlosta, Pierre I. Karakiewicz, Motoo Araki, Shahrokh F. Shariat
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Urology
Subjects:
Concomitant medications
Proton pump inhibitors
Antibiotics, steroids
Opioids
Histamine type-2 receptor antagonists
Immune checkpoint inhibitors
Online Access:https://doi.org/10.1186/s12894-025-01754-2
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