Potential for a Combined Oral Inactivated Whole-Cell Vaccine Against ETEC and <i>Shigella</i>: Preclinical Studies Supporting Feasibility

Potential for a Combined Oral Inactivated Whole-Cell Vaccine Against ETEC and <i>Shigella</i>: Preclinical Studies Supporting Feasibility

Background: Enteric disease caused by <i>Shigella</i>, <i>Campylobacter</i>, and enterotoxigenic <i>Escherichia coli</i> (ETEC) represents a significant global health burden, particularly among children in low-resource settings. However, no licensed vaccines are c...

Full description

Saved in:

Bibliographic Details
Main Authors:	Manuela Terrinoni, Jan Holmgren, Kevin Ross Turbyfill, Lillian Van De Verg, Nicole Maier, Richard Walker
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Vaccines
Subjects:	combined vaccine oral vaccine ETEC vaccine <i>Shigella</i> vaccine dmLT adjuvant mucosal immunity
Online Access:	https://www.mdpi.com/2076-393X/13/5/513
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

<i>Shigella</i> Mutant with Truncated O-Antigen as an Enteric Multi-Pathogen Vaccine Platform
by: Jae-Ouk Kim, et al.
Published: (2025-05-01)

Targeting Enterotoxins: Advancing Vaccine Development for Enterotoxigenic <i>Escherichia coli</i> ETEC
by: Josune Salvador-Erro, et al.
Published: (2025-02-01)

A Candidate Ac<sub>3</sub>-S-LPS Vaccine Against <i>S. flexneri</i> 1b, 2a, 3a, 6, and Y Activates Long-Lived Systemic and Mucosal Immune Responses in Healthy Volunteers: Results of an Open-Label, Randomized 2 Clinical Trial
by: Vladimir A. Ledov, et al.
Published: (2025-02-01)

Immunogenicity of RSV Fusion Protein Adsorbed to Non-Pathogenic <i>Bacillus subtilis</i> Spores: Implications for Mucosal Vaccine Delivery in Nonclinical Animal Models
by: Jianying Xiao, et al.
Published: (2025-05-01)

WHO Workshop Report: Regulatory Science to Inform Clinical Pathways for Shigella Vaccines Intended for Use in Children in Low- and Middle-Income Countries
by: Robert W. Kaminski, et al.
Published: (2025-04-01)

The fusion subunit vaccine L-DBF protects aged mice against heterologous lethal Shigella challenge after prior exposure
by: Md Shafiullah Parvej, et al.
Published: (2025-06-01)

Promising directions for vaccine development to prevent shigellosis
by: M. V. Abramtseva, et al.
Published: (2022-10-01)

Innovative adjuvant strategies for next-generation pertussis vaccines
by: Ge Yu, et al.
Published: (2025-12-01)

Mucosal immunity and vaccination strategies: current insights and future perspectives
by: Zhihao Zhang, et al.
Published: (2025-08-01)

Evaluation of Seasonal Inactivated Influenza Vaccines Prophylactic Efficacy
by: K. V. Zhdanov, et al.
Published: (2022-11-01)

Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters
by: Yongjun Sui, et al.
Published: (2025-02-01)

Probiotic spore-based antigen delivery: a novel oral vaccine strategy against Vibrio infections in aquaculture
by: Marina De Stefano, et al.
Published: (2025-05-01)

λ-Red-Recombineering Live Attenuated ΔipaD Shigella dysenteriae from Iranian Isolates as A Candidate of Vaccine
by: M Heidari
Published: (2012-03-01)

Unraveling <i>Helicobacter pylori</i>: Insights into Pathogenesis, Immune Evasion, and Progress Toward Effective Vaccination
by: Ayman Elbehiry, et al.
Published: (2025-07-01)

Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella
by: Ti Lu, et al.
Published: (2025-04-01)

CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
by: V. A. Lyodov, et al.
Published: (2014-07-01)

Protein nanocages: A new frontier in mucosal vaccine delivery and immune activation
by: Lavanya Agnes Angalene J, et al.
Published: (2025-12-01)

Mucosal immunotherapy targeting APC in lung disease
by: Yangqi Liu, et al.
Published: (2025-04-01)

Induction of protective immune responses at respiratory mucosal sites
by: Seok-Chan Park, et al.
Published: (2024-12-01)

Mucosal Vaccination Against SARS-CoV-2 Using Human Probiotic <i>Bacillus subtilis</i> Spores as an Adjuvant Induces Potent Systemic and Mucosal Immunity
by: Raul Ramos Pupo, et al.
Published: (2025-07-01)

Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella
by: Arlo Z. Randall, et al.
Published: (2025-05-01)

Vaccine hesitancy among parents of children with chronic diseases of different pathophysiology: a cross-sectional study in Sivas, Türkiye
by: Ayça Kömürlüoğlu, et al.
Published: (2025-05-01)

mRNA Galsomes Vaccine Protects Budgerigars Against Virulent <i>Chlamydia psittaci</i> Challenge
by: Anne De Meyst, et al.
Published: (2025-02-01)

Oral Delivery of <i>Lactococcus lactis</i> Expressing Full-Length S Protein via Alginate–Chitosan Capsules Induces Immune Protection Against PEDV Infection in Mice
by: Miaoyan Yang, et al.
Published: (2025-04-01)

Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium
by: Patricia García, et al.
Published: (2025-06-01)

Immune and Safety Analysis of <i>ultra</i>IPV<sup>TM</sup>, a Novel UVC-Inactivated Polio Vaccine
by: David A. MacLeod, et al.
Published: (2025-06-01)

Harnessing <i>Bacillus subtilis</i> Spore Surface Display (BSSD) Technology for Mucosal Vaccines and Drug Delivery: Innovations in Respiratory Virus Immunization
by: Howra Bahrulolum, et al.
Published: (2024-11-01)

Recent developments of vaccines for older adults: Adjuvants and beyond
by: Luca Pangrazzi, et al.
Published: (2025-12-01)

Toll-like receptor agonists as cancer vaccine adjuvants
by: Donghwan Jeon, et al.
Published: (2024-12-01)

Human papillomavirus vaccines: organisation and experience of preclinical studies
by: A. S. Korovkin, et al.
Published: (2024-10-01)

Understanding the etiology of diarrheal illness in Cambodia in a case-control study from 2020 to 2023
by: Paksathorn Kietsiri, et al.
Published: (2025-05-01)

Optimizing immunogenicity and product presentation of a SARS-CoV-2 subunit vaccine composition: effects of delivery route, heterologous regimens with self-amplifying RNA vaccines, and lyophilization
by: William R. Lykins, et al.
Published: (2024-12-01)

An Outbreak of Multidrug-Resistant <i>Shigella flexneri</i> Serotype 2a Among People Experiencing Homelessness in Vancouver
by: Victor Leung, et al.
Published: (2025-04-01)

Efficacy of LaAg Vaccine Associated with Saponin Against <i>Leishmania amazonensis</i> Infection
by: Mirian França de Mello, et al.
Published: (2025-01-01)

FcRn-Driven Nanoengineered Mucosal Vaccine with Multi-Epitope Fusion Induces Robust Dual Immunity and Long-Term Protection Against <i>Brucella</i>
by: Tingting Tian, et al.
Published: (2025-05-01)

Immunization with Inactivated <i>Bacillus subtilis</i> Spores Expressing TonB-Dependent Receptor (TBDR) Protects Against Multidrug-Resistant <i>Acinetobacter baumannii</i> Infection
by: Amalia A. Saperi, et al.
Published: (2025-06-01)

Medium- and Long-Term Immune Responses in the Small Intestine in Piglets from Oral Vaccination against <i>Escherichia coli</i>
by: Aida Miralles, et al.
Published: (2024-09-01)

A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS)
by: Rachel U. Lee, et al.
Published: (2024-12-01)

Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive)
by: Viktor V. Romanenko, et al.
Published: (2024-07-01)

Maternal and lactogenic immunity in gestating sows induced by adenoviruses expressing mucosal immunogens derived from porcine epidemic diarrhea virus
by: Namphueng Butkhot, et al.
Published: (2025-08-01)