Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that is critical to the pathophysiology of late complications and has important effects on outcomes. Omics techniques have expanded our investigational scope and depth into this phenomenon. In particular, metabolomics—t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Neurotherapeutics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878747924001910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575437593640960 |
|---|---|
| author | Bosco Seong Kyu Yang Spiros L. Blackburn Philip L. Lorenzi Huimahn A. Choi Aaron M. Gusdon |
| author_facet | Bosco Seong Kyu Yang Spiros L. Blackburn Philip L. Lorenzi Huimahn A. Choi Aaron M. Gusdon |
| author_sort | Bosco Seong Kyu Yang |
| collection | DOAJ |
| description | Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that is critical to the pathophysiology of late complications and has important effects on outcomes. Omics techniques have expanded our investigational scope and depth into this phenomenon. In particular, metabolomics—the study of small molecules, such as blood products, carbohydrates, amino acids, and lipids—can provide a snapshot of dynamic subcellular processes and thus broaden our understanding of molecular-level pathologic changes that lead to the systemic response after aSAH. Lipids are especially important due to their abundance in the circulating blood and numerous physiological roles. They are comprised of a wide variety of subspecies and are critical for cellular energy metabolism, the integrity of the blood-brain barrier, the formation of cell membranes, and intercellular signaling including neuroinflammation and ferroptosis. In this review, metabolomic and lipidomic pathways associated with aSAH are summarized, centering on key metabolites from each metabolomic domain. |
| format | Article |
| id | doaj-art-0380e98074ba4144b5a23af78eb273bb |
| institution | Kabale University |
| issn | 1878-7479 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurotherapeutics |
| spelling | doaj-art-0380e98074ba4144b5a23af78eb273bb2025-02-01T04:11:53ZengElsevierNeurotherapeutics1878-74792025-01-01221e00504Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhageBosco Seong Kyu Yang0Spiros L. Blackburn1Philip L. Lorenzi2Huimahn A. Choi3Aaron M. Gusdon4Department of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center, and Memorial Hermann Hospital at the Texas Medical Center, United StatesDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center, and Memorial Hermann Hospital at the Texas Medical Center, United StatesMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center (MDACC), United StatesDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center, and Memorial Hermann Hospital at the Texas Medical Center, United StatesDepartment of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center, and Memorial Hermann Hospital at the Texas Medical Center, United States; Corresponding author.Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that is critical to the pathophysiology of late complications and has important effects on outcomes. Omics techniques have expanded our investigational scope and depth into this phenomenon. In particular, metabolomics—the study of small molecules, such as blood products, carbohydrates, amino acids, and lipids—can provide a snapshot of dynamic subcellular processes and thus broaden our understanding of molecular-level pathologic changes that lead to the systemic response after aSAH. Lipids are especially important due to their abundance in the circulating blood and numerous physiological roles. They are comprised of a wide variety of subspecies and are critical for cellular energy metabolism, the integrity of the blood-brain barrier, the formation of cell membranes, and intercellular signaling including neuroinflammation and ferroptosis. In this review, metabolomic and lipidomic pathways associated with aSAH are summarized, centering on key metabolites from each metabolomic domain.http://www.sciencedirect.com/science/article/pii/S1878747924001910MetabolomeLipidomeAneurysmal subarachnoid hemorrhage |
| spellingShingle | Bosco Seong Kyu Yang Spiros L. Blackburn Philip L. Lorenzi Huimahn A. Choi Aaron M. Gusdon Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage Neurotherapeutics Metabolome Lipidome Aneurysmal subarachnoid hemorrhage |
| title | Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage |
| title_full | Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage |
| title_fullStr | Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage |
| title_full_unstemmed | Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage |
| title_short | Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage |
| title_sort | metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage |
| topic | Metabolome Lipidome Aneurysmal subarachnoid hemorrhage |
| url | http://www.sciencedirect.com/science/article/pii/S1878747924001910 |
| work_keys_str_mv | AT boscoseongkyuyang metabolomicandlipidomicpathwaysinaneurysmalsubarachnoidhemorrhage AT spiroslblackburn metabolomicandlipidomicpathwaysinaneurysmalsubarachnoidhemorrhage AT philipllorenzi metabolomicandlipidomicpathwaysinaneurysmalsubarachnoidhemorrhage AT huimahnachoi metabolomicandlipidomicpathwaysinaneurysmalsubarachnoidhemorrhage AT aaronmgusdon metabolomicandlipidomicpathwaysinaneurysmalsubarachnoidhemorrhage |