Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines
In therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/785634 |
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| _version_ | 1850232009476014080 |
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| author | Cleo Goyvaerts Karine Breckpot |
| author_facet | Cleo Goyvaerts Karine Breckpot |
| author_sort | Cleo Goyvaerts |
| collection | DOAJ |
| description | In therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic research started to investigate the potential benefit of targeting these subtypes in situ. This review will discuss which antigen-presenting cell subtypes are at play and how they have been targeted and finally question the true meaning of targeting antitumor-based vaccines. |
| format | Article |
| id | doaj-art-03808a9aba5346ef9267b2ba4523ca05 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-03808a9aba5346ef9267b2ba4523ca052025-08-20T02:03:19ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/785634785634Pros and Cons of Antigen-Presenting Cell Targeted Tumor VaccinesCleo Goyvaerts0Karine Breckpot1Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, 1090 Brussels, BelgiumLaboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, 1090 Brussels, BelgiumIn therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic research started to investigate the potential benefit of targeting these subtypes in situ. This review will discuss which antigen-presenting cell subtypes are at play and how they have been targeted and finally question the true meaning of targeting antitumor-based vaccines.http://dx.doi.org/10.1155/2015/785634 |
| spellingShingle | Cleo Goyvaerts Karine Breckpot Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines Journal of Immunology Research |
| title | Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines |
| title_full | Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines |
| title_fullStr | Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines |
| title_full_unstemmed | Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines |
| title_short | Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines |
| title_sort | pros and cons of antigen presenting cell targeted tumor vaccines |
| url | http://dx.doi.org/10.1155/2015/785634 |
| work_keys_str_mv | AT cleogoyvaerts prosandconsofantigenpresentingcelltargetedtumorvaccines AT karinebreckpot prosandconsofantigenpresentingcelltargetedtumorvaccines |