Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges
Periodontal disease (PD) is a chronic inflammatory condition that affects the teeth and their supporting tissues, ultimately culminating in tooth loss. Currently, treatment modalities, such as systemic and local administration of antibiotics, serve to mitigate the progression of inflammation yet fal...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1469733/full |
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| author | Ye Feng Hong-Peng Li |
| author_facet | Ye Feng Hong-Peng Li |
| author_sort | Ye Feng |
| collection | DOAJ |
| description | Periodontal disease (PD) is a chronic inflammatory condition that affects the teeth and their supporting tissues, ultimately culminating in tooth loss. Currently, treatment modalities, such as systemic and local administration of antibiotics, serve to mitigate the progression of inflammation yet fall short in restoring the original anatomical structure and physiological function of periodontal tissues. Biocompatible material-based tissue engineering seems to be a promising therapeutic strategy for treating PD. Collagen, a component of the extracellular matrix commonly used for tissue engineering, has been regarded as a promising biogenic material for tissue regeneration owing to its high cell-activating and biocompatible properties. The structural and chemical similarities between collagen and components of the oral tissue extracellular matrix render it a promising candidate for dental regeneration. This review explored the properties of collagen and its current applications in periodontal regeneration. We also discussed the recent progression in collagen therapies and preparation techniques. The review also scrutinizes the pros and cons associated with the application of collagen-based biomaterials in PD treatment, aiming to pave the way for future applications of collagen-based biomaterials in the management of PD. |
| format | Article |
| id | doaj-art-03802da19f5a43ef9e22eadf8833726c |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-03802da19f5a43ef9e22eadf8833726c2024-12-05T04:25:54ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-12-011210.3389/fbioe.2024.14697331469733Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challengesYe Feng0Hong-Peng Li1School of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKunshan Hospital of Chinese Medicine, Affiliated Hospital of Yangzhou University, Kunshan, ChinaPeriodontal disease (PD) is a chronic inflammatory condition that affects the teeth and their supporting tissues, ultimately culminating in tooth loss. Currently, treatment modalities, such as systemic and local administration of antibiotics, serve to mitigate the progression of inflammation yet fall short in restoring the original anatomical structure and physiological function of periodontal tissues. Biocompatible material-based tissue engineering seems to be a promising therapeutic strategy for treating PD. Collagen, a component of the extracellular matrix commonly used for tissue engineering, has been regarded as a promising biogenic material for tissue regeneration owing to its high cell-activating and biocompatible properties. The structural and chemical similarities between collagen and components of the oral tissue extracellular matrix render it a promising candidate for dental regeneration. This review explored the properties of collagen and its current applications in periodontal regeneration. We also discussed the recent progression in collagen therapies and preparation techniques. The review also scrutinizes the pros and cons associated with the application of collagen-based biomaterials in PD treatment, aiming to pave the way for future applications of collagen-based biomaterials in the management of PD.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1469733/fullcollagenbiomaterialsperiodontal diseaseperiodontal regenerationapplication |
| spellingShingle | Ye Feng Hong-Peng Li Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges Frontiers in Bioengineering and Biotechnology collagen biomaterials periodontal disease periodontal regeneration application |
| title | Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges |
| title_full | Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges |
| title_fullStr | Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges |
| title_full_unstemmed | Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges |
| title_short | Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges |
| title_sort | optimizing collagen based biomaterials for periodontal regeneration clinical opportunities and challenges |
| topic | collagen biomaterials periodontal disease periodontal regeneration application |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1469733/full |
| work_keys_str_mv | AT yefeng optimizingcollagenbasedbiomaterialsforperiodontalregenerationclinicalopportunitiesandchallenges AT hongpengli optimizingcollagenbasedbiomaterialsforperiodontalregenerationclinicalopportunitiesandchallenges |