The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights
The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. Recent research highlights the intricate interactions between gut microbiota and RNA, especially non-coding RNAs, in regulating metabolic processes. Dysbiosis of t...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1504395/full |
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| author | Zhuo Huang Zhuo Huang Qinyan Yao Qinyan Yao Shuang Ma Shuang Ma Jinjie Zhou Jinjie Zhou Xiaoxuan Wang Xiaoxuan Wang Qingguo Meng Qingguo Meng Yaxin Liu Yaxin Liu Zihan Yu Zihan Yu Xin Chen Xin Chen |
| author_facet | Zhuo Huang Zhuo Huang Qinyan Yao Qinyan Yao Shuang Ma Shuang Ma Jinjie Zhou Jinjie Zhou Xiaoxuan Wang Xiaoxuan Wang Qingguo Meng Qingguo Meng Yaxin Liu Yaxin Liu Zihan Yu Zihan Yu Xin Chen Xin Chen |
| author_sort | Zhuo Huang |
| collection | DOAJ |
| description | The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. Recent research highlights the intricate interactions between gut microbiota and RNA, especially non-coding RNAs, in regulating metabolic processes. Dysbiosis of the gut microbiota has been linked to metabolic disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) and metabolic heart disease. Microbial metabolites, including short-chain fatty acids (SCFAs), modulate RNA expression, influencing lipid metabolism, glucose regulation, and inflammatory responses. Additionally, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) serve as critical regulators in these processes, with emerging evidence showing that gut-derived metabolites affect post-transcriptional gene regulation. This review synthesizes the current understanding of the gut microbiota-RNA axis and its role in metabolic diseases. By exploring the molecular mechanisms, particularly how gut microbiota-derived signals modulate RNA pathways, the review underscores the potential of targeting this axis for therapeutic interventions. Furthermore, it examines how dysbiosis leads to epigenetic changes such as m6A RNA methylation, contributing to disease pathogenesis. These insights offer a new perspective on the prevention and treatment of metabolic diseases, with potential applications in personalized medicine. |
| format | Article |
| id | doaj-art-037f5823219f4cc4a497328d722792cc |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-037f5823219f4cc4a497328d722792cc2025-01-29T06:46:05ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.15043951504395The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insightsZhuo Huang0Zhuo Huang1Qinyan Yao2Qinyan Yao3Shuang Ma4Shuang Ma5Jinjie Zhou6Jinjie Zhou7Xiaoxuan Wang8Xiaoxuan Wang9Qingguo Meng10Qingguo Meng11Yaxin Liu12Yaxin Liu13Zihan Yu14Zihan Yu15Xin Chen16Xin Chen17Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, ChinaThe gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. Recent research highlights the intricate interactions between gut microbiota and RNA, especially non-coding RNAs, in regulating metabolic processes. Dysbiosis of the gut microbiota has been linked to metabolic disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) and metabolic heart disease. Microbial metabolites, including short-chain fatty acids (SCFAs), modulate RNA expression, influencing lipid metabolism, glucose regulation, and inflammatory responses. Additionally, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) serve as critical regulators in these processes, with emerging evidence showing that gut-derived metabolites affect post-transcriptional gene regulation. This review synthesizes the current understanding of the gut microbiota-RNA axis and its role in metabolic diseases. By exploring the molecular mechanisms, particularly how gut microbiota-derived signals modulate RNA pathways, the review underscores the potential of targeting this axis for therapeutic interventions. Furthermore, it examines how dysbiosis leads to epigenetic changes such as m6A RNA methylation, contributing to disease pathogenesis. These insights offer a new perspective on the prevention and treatment of metabolic diseases, with potential applications in personalized medicine.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1504395/fullRNAmetabolic diseasesgut microbiotametabolismmicrobial metabolites |
| spellingShingle | Zhuo Huang Zhuo Huang Qinyan Yao Qinyan Yao Shuang Ma Shuang Ma Jinjie Zhou Jinjie Zhou Xiaoxuan Wang Xiaoxuan Wang Qingguo Meng Qingguo Meng Yaxin Liu Yaxin Liu Zihan Yu Zihan Yu Xin Chen Xin Chen The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights Frontiers in Microbiology RNA metabolic diseases gut microbiota metabolism microbial metabolites |
| title | The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights |
| title_full | The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights |
| title_fullStr | The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights |
| title_full_unstemmed | The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights |
| title_short | The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights |
| title_sort | synergistic role of gut microbiota and rna in metabolic diseases mechanisms and therapeutic insights |
| topic | RNA metabolic diseases gut microbiota metabolism microbial metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1504395/full |
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