Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice
Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Resul...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/530501 |
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| author | Guang-ping Ruan Xiang Yao Shuang-juan Yang Jin-xiang Wang Fan Shu Zi-an Li Ju-fen Liu Rong-qing Pang Xing-hua Pan |
| author_facet | Guang-ping Ruan Xiang Yao Shuang-juan Yang Jin-xiang Wang Fan Shu Zi-an Li Ju-fen Liu Rong-qing Pang Xing-hua Pan |
| author_sort | Guang-ping Ruan |
| collection | DOAJ |
| description | Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Results. After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. Conclusions. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice. |
| format | Article |
| id | doaj-art-03712de3df4f4960b9fc1815d2baf7bc |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-03712de3df4f4960b9fc1815d2baf7bc2025-08-20T02:03:18ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/530501530501Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas MiceGuang-ping Ruan0Xiang Yao1Shuang-juan Yang2Jin-xiang Wang3Fan Shu4Zi-an Li5Ju-fen Liu6Rong-qing Pang7Xing-hua Pan8Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaKunming Biological Diversity Regional Center of Large Apparatus and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaStem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, ChinaBackground. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Results. After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. Conclusions. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.http://dx.doi.org/10.1155/2014/530501 |
| spellingShingle | Guang-ping Ruan Xiang Yao Shuang-juan Yang Jin-xiang Wang Fan Shu Zi-an Li Ju-fen Liu Rong-qing Pang Xing-hua Pan Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice Journal of Immunology Research |
| title | Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice |
| title_full | Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice |
| title_fullStr | Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice |
| title_full_unstemmed | Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice |
| title_short | Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice |
| title_sort | transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in b6 fas mice |
| url | http://dx.doi.org/10.1155/2014/530501 |
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