Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules
The new Italian cytological classification (2014) of thyroid nodules replaced the TIR3 category of the old classification (2007) with two subclasses, TIR3A and TIR3B, with the aim of reducing the rate of surgery for benign diseases. Moreover, thyroid imaging reporting and data system (TI-RADS) score...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/9692304 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849305154450358272 |
|---|---|
| author | Salvatore Ulisse Daniela Bosco Francesco Nardi Angela Nesca Eleonora D’Armiento Valeria Guglielmino Corrado De Vito Salvatore Sorrenti Daniele Pironi Francesco Tartaglia Stefano Arcieri Antonio Catania Massimo Monti Angelo Filippini Valeria Ascoli |
| author_facet | Salvatore Ulisse Daniela Bosco Francesco Nardi Angela Nesca Eleonora D’Armiento Valeria Guglielmino Corrado De Vito Salvatore Sorrenti Daniele Pironi Francesco Tartaglia Stefano Arcieri Antonio Catania Massimo Monti Angelo Filippini Valeria Ascoli |
| author_sort | Salvatore Ulisse |
| collection | DOAJ |
| description | The new Italian cytological classification (2014) of thyroid nodules replaced the TIR3 category of the old classification (2007) with two subclasses, TIR3A and TIR3B, with the aim of reducing the rate of surgery for benign diseases. Moreover, thyroid imaging reporting and data system (TI-RADS) score appears to ameliorate the stratification of the malignancy risk. We evaluated whether the new Italian classification has improved diagnostic accuracy and whether its association with TI-RADS score could improve malignancy prediction. We retrospectively analyzed 70 nodules from 70 patients classified as TIR3 according to the old Italian classification who underwent surgery for histological diagnosis. Of these, 51 were available for cytological revision according to the new Italian cytological classification. Risk of malignancy was determined for TIR3A and TIR3B, TI-RADS score, and their combination. A different rate of malignancy (p=0.0286) between TIR3A (13.04%) and TIR3B (44.44%) was observed. Also TI-RADS score is significantly (p=0.003) associated with malignancy. By combining cytology and TI-RADS score, patients could be divided into three groups with low (8.3%), intermediate (21.4%), and high (80%) risk of malignancy. In conclusion, the new Italian cytological classification has an improved diagnostic accuracy. Interestingly, the combination of cytology and TI-RADS score offers a better stratification of the malignancy risk. |
| format | Article |
| id | doaj-art-036b9b6c7e634fcb9f37922fc4ebfeb8 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-036b9b6c7e634fcb9f37922fc4ebfeb82025-08-20T03:55:32ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/96923049692304Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate NodulesSalvatore Ulisse0Daniela Bosco1Francesco Nardi2Angela Nesca3Eleonora D’Armiento4Valeria Guglielmino5Corrado De Vito6Salvatore Sorrenti7Daniele Pironi8Francesco Tartaglia9Stefano Arcieri10Antonio Catania11Massimo Monti12Angelo Filippini13Valeria Ascoli14Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Public Health and Infectious Disease, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyThe new Italian cytological classification (2014) of thyroid nodules replaced the TIR3 category of the old classification (2007) with two subclasses, TIR3A and TIR3B, with the aim of reducing the rate of surgery for benign diseases. Moreover, thyroid imaging reporting and data system (TI-RADS) score appears to ameliorate the stratification of the malignancy risk. We evaluated whether the new Italian classification has improved diagnostic accuracy and whether its association with TI-RADS score could improve malignancy prediction. We retrospectively analyzed 70 nodules from 70 patients classified as TIR3 according to the old Italian classification who underwent surgery for histological diagnosis. Of these, 51 were available for cytological revision according to the new Italian cytological classification. Risk of malignancy was determined for TIR3A and TIR3B, TI-RADS score, and their combination. A different rate of malignancy (p=0.0286) between TIR3A (13.04%) and TIR3B (44.44%) was observed. Also TI-RADS score is significantly (p=0.003) associated with malignancy. By combining cytology and TI-RADS score, patients could be divided into three groups with low (8.3%), intermediate (21.4%), and high (80%) risk of malignancy. In conclusion, the new Italian cytological classification has an improved diagnostic accuracy. Interestingly, the combination of cytology and TI-RADS score offers a better stratification of the malignancy risk.http://dx.doi.org/10.1155/2017/9692304 |
| spellingShingle | Salvatore Ulisse Daniela Bosco Francesco Nardi Angela Nesca Eleonora D’Armiento Valeria Guglielmino Corrado De Vito Salvatore Sorrenti Daniele Pironi Francesco Tartaglia Stefano Arcieri Antonio Catania Massimo Monti Angelo Filippini Valeria Ascoli Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules International Journal of Endocrinology |
| title | Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules |
| title_full | Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules |
| title_fullStr | Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules |
| title_full_unstemmed | Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules |
| title_short | Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules |
| title_sort | thyroid imaging reporting and data system score combined with the new italian classification for thyroid cytology improves the clinical management of indeterminate nodules |
| url | http://dx.doi.org/10.1155/2017/9692304 |
| work_keys_str_mv | AT salvatoreulisse thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT danielabosco thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT francesconardi thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT angelanesca thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT eleonoradarmiento thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT valeriaguglielmino thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT corradodevito thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT salvatoresorrenti thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT danielepironi thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT francescotartaglia thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT stefanoarcieri thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT antoniocatania thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT massimomonti thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT angelofilippini thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules AT valeriaascoli thyroidimagingreportinganddatasystemscorecombinedwiththenewitalianclassificationforthyroidcytologyimprovestheclinicalmanagementofindeterminatenodules |