Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin
Rosmarinus officinalis, L. (Lamiaceae) offers medicinal potential against hepatotoxicity and nephrotoxicity Due to its antioxidant and anti-toxicity properties. The objective, of this research is to explore into the ethanol extract of Rosmarinus officianalis leaves and its efficacy against ...
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College of Veterinary Medicine, University of Basrah, Iraq
2022-09-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_175775_4aa3c19eb2d08a553637bc6fcd52d676.pdf |
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| author | Shireen Hasan Ahlam Al-Rikaby |
| author_facet | Shireen Hasan Ahlam Al-Rikaby |
| author_sort | Shireen Hasan |
| collection | DOAJ |
| description | Rosmarinus officinalis, L. (Lamiaceae) offers medicinal potential against hepatotoxicity and nephrotoxicity Due to its antioxidant and anti-toxicity properties. The objective, of this research is to explore into the ethanol extract of Rosmarinus officianalis leaves and its efficacy against cypremethrin induce toxicity in The liver and The kidney of male rabbits. Forty male rabbits were employed in this experience, group one ( without exposure); rabbits received corn oil ( 1 ml) group two; rabbits oral exposure to cypermethrin with dose (66.5 mg/kg/b.w ( 1/10 of LD50) dissolved in corn oil , group three( protective group) received rosemary extract with dose 100mg/kg plus cypermethrine with dose 66.5 mg/kg/b.w., group four received rosemary extract with dose 200mg/kg plus cypermethrine with dose 66.5 mg/kg/b.w. the above doses once per day for 6 weeks respectively.In accordance with the current study's findings, liver enzyme levels significantly increased. ALT,ALSand ALP),Lipid profile (TC,TG.LDL-cand VLDL_c) and kidney function tests (urea, a creatinine, uric acid and blood urea, nitrogen concentrations ) but significant decrease in (Total protein and HDL_ c value ) in the treated group with cypermethrin , .whereas the animals received rosemary extract in both dose plus cypermethrin produced notable decrease in the levels of the vital parameters of the liver and kidneys are with the normal level. : the current study displayed that the Rosmarinus officinalis has antitoxicity activities as seen via decreasing liver enzymes, lipid profile and kidney function tests is accompanied by elevated the levels of total protein . |
| format | Article |
| id | doaj-art-035a6461a20d44d1bae4e85e3b689b81 |
| institution | DOAJ |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-035a6461a20d44d1bae4e85e3b689b812025-08-20T03:09:55ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562022-09-01213587010.23975/bjvetr.2022.175775175775Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrinShireen Hasan0Ahlam Al-Rikaby1Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, IraqDepartment of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, IraqRosmarinus officinalis, L. (Lamiaceae) offers medicinal potential against hepatotoxicity and nephrotoxicity Due to its antioxidant and anti-toxicity properties. The objective, of this research is to explore into the ethanol extract of Rosmarinus officianalis leaves and its efficacy against cypremethrin induce toxicity in The liver and The kidney of male rabbits. Forty male rabbits were employed in this experience, group one ( without exposure); rabbits received corn oil ( 1 ml) group two; rabbits oral exposure to cypermethrin with dose (66.5 mg/kg/b.w ( 1/10 of LD50) dissolved in corn oil , group three( protective group) received rosemary extract with dose 100mg/kg plus cypermethrine with dose 66.5 mg/kg/b.w., group four received rosemary extract with dose 200mg/kg plus cypermethrine with dose 66.5 mg/kg/b.w. the above doses once per day for 6 weeks respectively.In accordance with the current study's findings, liver enzyme levels significantly increased. ALT,ALSand ALP),Lipid profile (TC,TG.LDL-cand VLDL_c) and kidney function tests (urea, a creatinine, uric acid and blood urea, nitrogen concentrations ) but significant decrease in (Total protein and HDL_ c value ) in the treated group with cypermethrin , .whereas the animals received rosemary extract in both dose plus cypermethrin produced notable decrease in the levels of the vital parameters of the liver and kidneys are with the normal level. : the current study displayed that the Rosmarinus officinalis has antitoxicity activities as seen via decreasing liver enzymes, lipid profile and kidney function tests is accompanied by elevated the levels of total protein . https://bjvr.uobasrah.edu.iq/article_175775_4aa3c19eb2d08a553637bc6fcd52d676.pdfcypermethrinliverrosemary |
| spellingShingle | Shireen Hasan Ahlam Al-Rikaby Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin Basrah Journal of Veterinary Research cypermethrin liver rosemary |
| title | Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin |
| title_full | Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin |
| title_fullStr | Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin |
| title_full_unstemmed | Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin |
| title_short | Study the ability of rosemary leaf Ethanol extract to protect male rabbits’ liver and kidney against poisoning cypermethrin |
| title_sort | study the ability of rosemary leaf ethanol extract to protect male rabbits liver and kidney against poisoning cypermethrin |
| topic | cypermethrin liver rosemary |
| url | https://bjvr.uobasrah.edu.iq/article_175775_4aa3c19eb2d08a553637bc6fcd52d676.pdf |
| work_keys_str_mv | AT shireenhasan studytheabilityofrosemaryleafethanolextracttoprotectmalerabbitsliverandkidneyagainstpoisoningcypermethrin AT ahlamalrikaby studytheabilityofrosemaryleafethanolextracttoprotectmalerabbitsliverandkidneyagainstpoisoningcypermethrin |