Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease

Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease

Accumulating evidence links osteopontin (OPN), a pro-fibrogenic extracellular matrix protein, to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, liver tissues isolated from non-alcoholic steatohepatitis (NASH) patients expressed higher OPN than those of controls. Howeve...

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Bibliographic Details
Main Authors: Min Tang, Yan Jiang, Haoyu Jia, Bhuvanesh Kinish Patpur, Bo Yang, Jing Li, Changqing Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Osteopontin
autophagy
lipid
nonalcoholic fatty liver disease
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1699822
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