A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii

A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii

BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAB)-caused severe pneumonia is associated with high mortality rates, and treatment options are limited. Tetracyclines, including tigecycline and omadacycline, have in vitro activity against CRAB. We conducted this study to explore the efficac...

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Bibliographic Details
Main Authors: Dayu Chen, Yechao Chen, Na Hu, Qiaoling Gu, Jingjing Kan, Jinchun Liu, Haixia Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
Subjects:
omadacycline
tigecycline
carbapenem-resistant Acinetobacter baumannii
pneumonia
retrospective matched cohort study
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1597860/full
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