Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

Abstract Ultrasensitive antigen recognition between T lymphocytes and cognate targets via immunological synapse (IS) formation enables live cell-based antigen-specific T cell detection. However, unpredictable antigen processing and major histocompatibility complex (MHC) turnover limit specificity. H...

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Main Authors: Chung-Yao Hsu, Po-Cheng Tsai, Jung-Chen Lin, Chen-Hsueh Pai, Yun-Jui Teng, Bing-Yu Yao, Cheng-Yin Fei, Gwo Harn Max Shiau, Leon CW Lin, Sean Lo, Hung-Chih Yang, Che-Ming Jack Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60321-3
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