Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections
The escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth of nanotechnology interdisciplinary research and fu...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/4/952 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850180435596804096 |
|---|---|
| author | Eudald Casals Muriel F. Gusta Neus Bastus Jordi Rello Victor Puntes |
| author_facet | Eudald Casals Muriel F. Gusta Neus Bastus Jordi Rello Victor Puntes |
| author_sort | Eudald Casals |
| collection | DOAJ |
| description | The escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth of nanotechnology interdisciplinary research and funding programs in the 2000s, silver ions have re-emerged as potent antimicrobial agents, offering a promising complement to conventional therapies. This therapeutic potential is nowadays explored through the use of silver nanoparticles (AgNPs) as sources for silver ions release. Recent studies have shown that controlled silver ion release enhances the efficacy of common antibiotics. This can be attributed to the energetically demanding nature of the bacterial response to silver, which weakens bacterial metabolism and, in turn, overwhelms bacterial defenses and increases antibiotic effectiveness. Herein, historical insights into the use of colloidal silver and AgNPs are combined with a review of recent research on the exploitation of the synergistic effect between AgNPs and antibiotics as a promising strategy against MDR pathogens. |
| format | Article |
| id | doaj-art-034b89b59ee4491098649520f0cf3483 |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-034b89b59ee4491098649520f0cf34832025-08-20T02:18:10ZengMDPI AGMicroorganisms2076-26072025-04-0113495210.3390/microorganisms13040952Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant InfectionsEudald Casals0Muriel F. Gusta1Neus Bastus2Jordi Rello3Victor Puntes4Vall d’Hebron Institut de Recerca (VHIR), 08035 Barcelona, SpainCatalan Institute of Nanoscience & Nanotechnology (ICN2), Consejo Superior de Investigaciones Científicas (CSIC), The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193 Bellaterra, SpainCatalan Institute of Nanoscience & Nanotechnology (ICN2), Consejo Superior de Investigaciones Científicas (CSIC), The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193 Bellaterra, SpainCIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, SpainVall d’Hebron Institut de Recerca (VHIR), 08035 Barcelona, SpainThe escalating threat of antibiotic resistance demands innovative strategies against multidrug-resistant (MDR) microorganisms, particularly in hospital settings where such infections represent a major global health challenge. Since the rapid growth of nanotechnology interdisciplinary research and funding programs in the 2000s, silver ions have re-emerged as potent antimicrobial agents, offering a promising complement to conventional therapies. This therapeutic potential is nowadays explored through the use of silver nanoparticles (AgNPs) as sources for silver ions release. Recent studies have shown that controlled silver ion release enhances the efficacy of common antibiotics. This can be attributed to the energetically demanding nature of the bacterial response to silver, which weakens bacterial metabolism and, in turn, overwhelms bacterial defenses and increases antibiotic effectiveness. Herein, historical insights into the use of colloidal silver and AgNPs are combined with a review of recent research on the exploitation of the synergistic effect between AgNPs and antibiotics as a promising strategy against MDR pathogens.https://www.mdpi.com/2076-2607/13/4/952antibiotic resistancesilver nanoparticlesmultidrug-resistant pathogensantimicrobial synergycontrolled ion release |
| spellingShingle | Eudald Casals Muriel F. Gusta Neus Bastus Jordi Rello Victor Puntes Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections Microorganisms antibiotic resistance silver nanoparticles multidrug-resistant pathogens antimicrobial synergy controlled ion release |
| title | Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections |
| title_full | Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections |
| title_fullStr | Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections |
| title_full_unstemmed | Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections |
| title_short | Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections |
| title_sort | silver nanoparticles and antibiotics a promising synergistic approach to multidrug resistant infections |
| topic | antibiotic resistance silver nanoparticles multidrug-resistant pathogens antimicrobial synergy controlled ion release |
| url | https://www.mdpi.com/2076-2607/13/4/952 |
| work_keys_str_mv | AT eudaldcasals silvernanoparticlesandantibioticsapromisingsynergisticapproachtomultidrugresistantinfections AT murielfgusta silvernanoparticlesandantibioticsapromisingsynergisticapproachtomultidrugresistantinfections AT neusbastus silvernanoparticlesandantibioticsapromisingsynergisticapproachtomultidrugresistantinfections AT jordirello silvernanoparticlesandantibioticsapromisingsynergisticapproachtomultidrugresistantinfections AT victorpuntes silvernanoparticlesandantibioticsapromisingsynergisticapproachtomultidrugresistantinfections |