Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions
This review explores the recent advancements and ongoing challenges in regenerating alveolar bone, which is essential for dental implants and periodontal health. It examines traditional techniques like guided bone regeneration and bone grafting, alongside newer methods such as stem cell therapy, gen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/61/1/20 |
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| author | Diana Marian Giuseppe Toro Giovanbattista D’Amico Maria Consiglia Trotta Michele D’Amico Alexandru Petre Ioana Lile Anca Hermenean Anca Fratila |
| author_facet | Diana Marian Giuseppe Toro Giovanbattista D’Amico Maria Consiglia Trotta Michele D’Amico Alexandru Petre Ioana Lile Anca Hermenean Anca Fratila |
| author_sort | Diana Marian |
| collection | DOAJ |
| description | This review explores the recent advancements and ongoing challenges in regenerating alveolar bone, which is essential for dental implants and periodontal health. It examines traditional techniques like guided bone regeneration and bone grafting, alongside newer methods such as stem cell therapy, gene therapy, and 3D bioprinting. Each approach is considered for its strengths in supporting bone growth and integration, especially in cases where complex bone defects make regeneration difficult. This review also looks at different biomaterials, from bioactive scaffolds to nanomaterials, assessing how well they encourage cell growth and healing. Personalized treatments, like customized 3D-printed scaffolds, show promise in enhancing bone formation and tissue compatibility. Additionally, signaling molecules, like bone morphogenetic proteins, play a crucial role in guiding the process of bone formation and remodeling. Despite these advances, challenges remain—particularly with severe bone loss and with refining biomaterials for more reliable, long-term outcomes. This review proposes combining advanced materials, regenerative technologies, and personalized approaches to achieve more effective and consistent outcomes in oral and maxillofacial surgery. |
| format | Article |
| id | doaj-art-0347dc00707149fa9e35edaf1dd2e362 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-0347dc00707149fa9e35edaf1dd2e3622025-01-24T13:40:16ZengMDPI AGMedicina1010-660X1648-91442024-12-016112010.3390/medicina61010020Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future DirectionsDiana Marian0Giuseppe Toro1Giovanbattista D’Amico2Maria Consiglia Trotta3Michele D’Amico4Alexandru Petre5Ioana Lile6Anca Hermenean7Anca Fratila8Department of Dentistry, Faculty of Dentistry, “Vasile Goldiș” Western University of Arad, 94-96 Revolutiei Blvd., 310025 Arad, RomaniaMultidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalySchool of Geriatrics, University of Studies of L’Aquila, 67010 L’Aquila, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Prosthodontics, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Dentistry, Faculty of Dentistry, “Vasile Goldiș” Western University of Arad, 94-96 Revolutiei Blvd., 310025 Arad, Romania“Aurel Ardelean” Institute of Life Sciences, “Vasile Goldiș” Western University of Arad, 310025 Arad, RomaniaDepartment of Dental Medicine and Nursing, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaThis review explores the recent advancements and ongoing challenges in regenerating alveolar bone, which is essential for dental implants and periodontal health. It examines traditional techniques like guided bone regeneration and bone grafting, alongside newer methods such as stem cell therapy, gene therapy, and 3D bioprinting. Each approach is considered for its strengths in supporting bone growth and integration, especially in cases where complex bone defects make regeneration difficult. This review also looks at different biomaterials, from bioactive scaffolds to nanomaterials, assessing how well they encourage cell growth and healing. Personalized treatments, like customized 3D-printed scaffolds, show promise in enhancing bone formation and tissue compatibility. Additionally, signaling molecules, like bone morphogenetic proteins, play a crucial role in guiding the process of bone formation and remodeling. Despite these advances, challenges remain—particularly with severe bone loss and with refining biomaterials for more reliable, long-term outcomes. This review proposes combining advanced materials, regenerative technologies, and personalized approaches to achieve more effective and consistent outcomes in oral and maxillofacial surgery.https://www.mdpi.com/1648-9144/61/1/20alveolar bone regenerationbiomaterialsguided bone regeneration |
| spellingShingle | Diana Marian Giuseppe Toro Giovanbattista D’Amico Maria Consiglia Trotta Michele D’Amico Alexandru Petre Ioana Lile Anca Hermenean Anca Fratila Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions Medicina alveolar bone regeneration biomaterials guided bone regeneration |
| title | Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions |
| title_full | Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions |
| title_fullStr | Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions |
| title_full_unstemmed | Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions |
| title_short | Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions |
| title_sort | challenges and innovations in alveolar bone regeneration a narrative review on materials techniques clinical outcomes and future directions |
| topic | alveolar bone regeneration biomaterials guided bone regeneration |
| url | https://www.mdpi.com/1648-9144/61/1/20 |
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