Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses

Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share common genes and pathomechanisms and are referred to as the ALS-FTD spectrum. A hallmark of ALS-FTD pathology is the abnormal aggregation of proteins, including Cu/Zn superoxide dismu...

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Bibliographic Details
Main Authors: Enza Maria Verde, Valentina Secco, Andrea Ghezzi, Jessica Mandrioli, Serena Carra
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
ALS-FTD
TDP-43
protein aggregation
stress granules
post-translational modifications
Online Access:https://www.mdpi.com/2073-4409/14/10/680
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