Pregnancy complications affect kynurenine pathway metabolite concentrations in umbilical cord blood

Pregnancy complications affect kynurenine pathway metabolite concentrations in umbilical cord blood

Abstract Background Tryptophan and its kynurenine pathway (KP) metabolites play key roles in modulating the immune system and vasculature, and exhibit both pro- and antioxidant properties, making them crucial for a healthy pregnancy and fetal development. Disruptions in the KP may impact both prenat...

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Main Authors: Michelle Broekhuizen, Heike Allenberg, Claude P. van der Ley, Sofie K. M. van Zundert, Zongye Cai, Martijn van Faassen, Daphne Merkus, A. H. Jan Danser, Anja Lange, Irwin K. M. Reiss, Matthias Heckmann
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Kynurenine pathway
Tryptophan
Pregnancy
Pregnancy complication
Umbilical cord blood
Fetus
Online Access:https://doi.org/10.1186/s12958-025-01436-6
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