Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation
Pre-transplant kidney biopsy is routinely used to decide whether kidneys from marginal donors should be transplanted as single or double trans-plantation. This is a 5-year extension of the follow-up of a previous study. In that study, graft outcomes were compared retrospectively between a group of 4...
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Troika Publisher
2020-11-01
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| Series: | Journal of Renal and Hepatic Disorders |
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| Online Access: | https://jrenhep.com/index.php/jrenhep/article/view/77 |
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| author | Paolo Carta Emma Bartaletti Giulia Ghiandai Leonardo Caroti Aida Larti Lorenzo Di Maria Lino Cirami |
| author_facet | Paolo Carta Emma Bartaletti Giulia Ghiandai Leonardo Caroti Aida Larti Lorenzo Di Maria Lino Cirami |
| author_sort | Paolo Carta |
| collection | DOAJ |
| description | Pre-transplant kidney biopsy is routinely used to decide whether kidneys from marginal donors should be transplanted as single or double trans-plantation. This is a 5-year extension of the follow-up of a previous study. In that study, graft outcomes were compared retrospectively between a group of 44 recipients of a single kidney graft from an extended criteria donor and a Karpinski histological score of 3 or less, and another group of 56 recipients of a single transplant with a Karpinski histological score of 4 or 5. After 5 years of transplantation, there was no difference between the two groups in terms of recipient’s serum creatinine levels (1.8 ± 0.5 vs 1.9 ± 0.6 mg/dL, P = 0.5), creatinine clearance (53 ± 23 vs 49 ± 27.0 mL/min, P = 0.6), or the rates of graft loss (41% vs 49%,P = 0.5). Therefore, the choice between single and double transplant should not be made only on the basis of histological score but should be done together with the evaluation of donor’s clinical parameters, especially the renal function. |
| format | Article |
| id | doaj-art-03384134d65d41cab97a4687b09e28b2 |
| institution | DOAJ |
| issn | 2207-3744 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | Troika Publisher |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj-art-03384134d65d41cab97a4687b09e28b22025-08-20T03:15:15ZengTroika PublisherJournal of Renal and Hepatic Disorders2207-37442020-11-014210.15586/jrenhep.v4i2.77Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of TransplantationPaolo Carta0Emma Bartaletti1Giulia Ghiandai2Leonardo Caroti3Aida Larti4Lorenzo Di Maria5Lino Cirami6Careggi University Hospital, Florence, ItalyCareggi University Hospital, Florence, ItalyCareggi University Hospital, Florence, ItalyCareggi University Hospital, Florence, ItalyCareggi University Hospital, Florence, Italy Careggi University Hospital, Florence, ItalyCareggi University Hospital, Florence, ItalyPre-transplant kidney biopsy is routinely used to decide whether kidneys from marginal donors should be transplanted as single or double trans-plantation. This is a 5-year extension of the follow-up of a previous study. In that study, graft outcomes were compared retrospectively between a group of 44 recipients of a single kidney graft from an extended criteria donor and a Karpinski histological score of 3 or less, and another group of 56 recipients of a single transplant with a Karpinski histological score of 4 or 5. After 5 years of transplantation, there was no difference between the two groups in terms of recipient’s serum creatinine levels (1.8 ± 0.5 vs 1.9 ± 0.6 mg/dL, P = 0.5), creatinine clearance (53 ± 23 vs 49 ± 27.0 mL/min, P = 0.6), or the rates of graft loss (41% vs 49%,P = 0.5). Therefore, the choice between single and double transplant should not be made only on the basis of histological score but should be done together with the evaluation of donor’s clinical parameters, especially the renal function.https://jrenhep.com/index.php/jrenhep/article/view/77kidney transplantation, extended criteria donors, Karpinski histological score, pre-implantation kidney biopsy |
| spellingShingle | Paolo Carta Emma Bartaletti Giulia Ghiandai Leonardo Caroti Aida Larti Lorenzo Di Maria Lino Cirami Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation Journal of Renal and Hepatic Disorders kidney transplantation, extended criteria donors, Karpinski histological score, pre-implantation kidney biopsy |
| title | Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation |
| title_full | Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation |
| title_fullStr | Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation |
| title_full_unstemmed | Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation |
| title_short | Histological Evaluation of Extended Criteria Donors: Donor’s Kidney Biopsy and Graft Outcome after 5 Years of Transplantation |
| title_sort | histological evaluation of extended criteria donors donor s kidney biopsy and graft outcome after 5 years of transplantation |
| topic | kidney transplantation, extended criteria donors, Karpinski histological score, pre-implantation kidney biopsy |
| url | https://jrenhep.com/index.php/jrenhep/article/view/77 |
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