A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy
Background: Vitamin D deficiency is documented to be more prevalent in Type 2 Diabetes Mellitus (T2DM) and is associated with diabetic nephropathy. Aim and Objective: To investigate the vitamin D status in T2DM patients with and without nephropathy in eastern part of southern India. Material and Met...
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Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2021-04-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
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| Online Access: | https://www.jkimsu.com/jkimsu-vol10no2/JKIMSU,%20Vol.%2010,%20No.%202,%20April-June%202021%20Page%20100-109.pdf |
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| author | Bhuneshwar Yadav Shashidhar KN Raveesha A Muninarayana C |
| author_facet | Bhuneshwar Yadav Shashidhar KN Raveesha A Muninarayana C |
| author_sort | Bhuneshwar Yadav |
| collection | DOAJ |
| description | Background: Vitamin D deficiency is documented to be more prevalent in Type 2 Diabetes Mellitus (T2DM) and is associated with diabetic nephropathy. Aim and Objective: To investigate the vitamin D status in T2DM patients with and without nephropathy in eastern part of southern India. Material and Methods: This cross-sectional study included 150 study subjects. Routine laboratory measurements were done using commercially available kits on Vitros 5, 1 FS auto analyzer from Ortho Clinical Diagnosis (OCD), United Kingdom, based on the principle of Reflectance Photometry. Serum 25-hydroxyvitamin D was measured by using chemiluminescence immunoassay methods. Results were analysed using IBM-SPSS version 20. Results: Vitamin D levels were observed to be lower in the diabetic nephropathy (18.44 ± 8.69 ng/mL) as compared to control (26.55 ± 7.88 ng/mL) and T2DM (19.64 ± 9.93 ng/mL) subjects and were correlated significantly with HbA1c and microalbumin. A markedly higher proportion of study subjects with vitamin D deficiency as well as insufficiency in T2DM and diabetic nephropathy group. Conclusion: Patients with type 2 diabetes and diabetic nephropathy had a low serum vitamin D level than healthy control. Vitamin D estimation in such patients may aid in the diagnosis and treatment as well as to prevent further complication. |
| format | Article |
| id | doaj-art-03374cc2341c4d3086047d8be788c05e |
| institution | OA Journals |
| issn | 2231-4261 2231-4261 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
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| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj-art-03374cc2341c4d3086047d8be788c05e2025-08-20T01:54:42ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612231-42612021-04-01102100109A Cross-sectional Study on Vitamin D Status in Patients with Diabetic NephropathyBhuneshwar Yadav0Shashidhar KN1Raveesha A2Muninarayana C3Department of Biochemistry, Sri Devaraj Urs Medical College, Tamaka, Kolar-563101 (Karnataka) IndiaDepartment of Biochemistry, Sri Devaraj Urs Medical College, Tamaka, Kolar-563101 (Karnataka) IndiaDepartment of Medicine, Sri Devaraj Urs Medical College, Tamaka, Kolar-563101 (Karnataka) IndiaDepartment of Community Medicine, Sri Devaraj Urs Medical College, Tamaka, Kolar-563101 (Karnataka) IndiaBackground: Vitamin D deficiency is documented to be more prevalent in Type 2 Diabetes Mellitus (T2DM) and is associated with diabetic nephropathy. Aim and Objective: To investigate the vitamin D status in T2DM patients with and without nephropathy in eastern part of southern India. Material and Methods: This cross-sectional study included 150 study subjects. Routine laboratory measurements were done using commercially available kits on Vitros 5, 1 FS auto analyzer from Ortho Clinical Diagnosis (OCD), United Kingdom, based on the principle of Reflectance Photometry. Serum 25-hydroxyvitamin D was measured by using chemiluminescence immunoassay methods. Results were analysed using IBM-SPSS version 20. Results: Vitamin D levels were observed to be lower in the diabetic nephropathy (18.44 ± 8.69 ng/mL) as compared to control (26.55 ± 7.88 ng/mL) and T2DM (19.64 ± 9.93 ng/mL) subjects and were correlated significantly with HbA1c and microalbumin. A markedly higher proportion of study subjects with vitamin D deficiency as well as insufficiency in T2DM and diabetic nephropathy group. Conclusion: Patients with type 2 diabetes and diabetic nephropathy had a low serum vitamin D level than healthy control. Vitamin D estimation in such patients may aid in the diagnosis and treatment as well as to prevent further complication.https://www.jkimsu.com/jkimsu-vol10no2/JKIMSU,%20Vol.%2010,%20No.%202,%20April-June%202021%20Page%20100-109.pdftype 2 diabetes mellitus25-hydroxyvitamin ddiabetic nephropathymicroalbuminurialipid profile |
| spellingShingle | Bhuneshwar Yadav Shashidhar KN Raveesha A Muninarayana C A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy Journal of Krishna Institute of Medical Sciences University type 2 diabetes mellitus 25-hydroxyvitamin d diabetic nephropathy microalbuminuria lipid profile |
| title | A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy |
| title_full | A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy |
| title_fullStr | A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy |
| title_full_unstemmed | A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy |
| title_short | A Cross-sectional Study on Vitamin D Status in Patients with Diabetic Nephropathy |
| title_sort | cross sectional study on vitamin d status in patients with diabetic nephropathy |
| topic | type 2 diabetes mellitus 25-hydroxyvitamin d diabetic nephropathy microalbuminuria lipid profile |
| url | https://www.jkimsu.com/jkimsu-vol10no2/JKIMSU,%20Vol.%2010,%20No.%202,%20April-June%202021%20Page%20100-109.pdf |
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