Glymphatic system: a self-purification circulation in brain
The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage. Aquaporin-4 (AQP4) plays a crucial role in driving flu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1528995/full |
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| author | Siying Chen Siying Chen Huijing Wang Lini Zhang Yingying Xi Yiying Lu Kailin Yu Yujie Zhu Izmailova Regina Yong Bi Fang Tong Fang Tong |
| author_facet | Siying Chen Siying Chen Huijing Wang Lini Zhang Yingying Xi Yiying Lu Kailin Yu Yujie Zhu Izmailova Regina Yong Bi Fang Tong Fang Tong |
| author_sort | Siying Chen |
| collection | DOAJ |
| description | The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage. Aquaporin-4 (AQP4) plays a crucial role in driving fluid within the PVS. The impairment to AQP4 is closely linked to the dysfunction of the glymphatic system. The function of the glymphatic system is less active during waking but enhanced during sleep. The efficiency of the glymphatic system decreases with aging. Damage to the glymphatic system will give rise to the development and progression of many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), chronic traumatic encephalopathy (CTE), and vascular dementia (VaD). Here, we reviewed previous research associated with the glymphatic system, including its concepts, principles, and influencing factors. We hypothesize that AQP4 could be a target for the prevention and treatment of certain brain diseases through the regulation on the glymphatic system. |
| format | Article |
| id | doaj-art-0331e32a40384ddbb841bcfb7e72407b |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-0331e32a40384ddbb841bcfb7e72407b2025-02-12T07:26:14ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-02-011910.3389/fncel.2025.15289951528995Glymphatic system: a self-purification circulation in brainSiying Chen0Siying Chen1Huijing Wang2Lini Zhang3Yingying Xi4Yiying Lu5Kailin Yu6Yujie Zhu7Izmailova Regina8Yong Bi9Fang Tong10Fang Tong11School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaDepartment of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaInstitute of Wound Prevention and Treatment, School of Fundamental Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaDepartment of Neurology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaThe glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage. Aquaporin-4 (AQP4) plays a crucial role in driving fluid within the PVS. The impairment to AQP4 is closely linked to the dysfunction of the glymphatic system. The function of the glymphatic system is less active during waking but enhanced during sleep. The efficiency of the glymphatic system decreases with aging. Damage to the glymphatic system will give rise to the development and progression of many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), chronic traumatic encephalopathy (CTE), and vascular dementia (VaD). Here, we reviewed previous research associated with the glymphatic system, including its concepts, principles, and influencing factors. We hypothesize that AQP4 could be a target for the prevention and treatment of certain brain diseases through the regulation on the glymphatic system.https://www.frontiersin.org/articles/10.3389/fncel.2025.1528995/fullglymphatic systemcerebral spinal fluidastrocyteAQP4brain disease |
| spellingShingle | Siying Chen Siying Chen Huijing Wang Lini Zhang Yingying Xi Yiying Lu Kailin Yu Yujie Zhu Izmailova Regina Yong Bi Fang Tong Fang Tong Glymphatic system: a self-purification circulation in brain Frontiers in Cellular Neuroscience glymphatic system cerebral spinal fluid astrocyte AQP4 brain disease |
| title | Glymphatic system: a self-purification circulation in brain |
| title_full | Glymphatic system: a self-purification circulation in brain |
| title_fullStr | Glymphatic system: a self-purification circulation in brain |
| title_full_unstemmed | Glymphatic system: a self-purification circulation in brain |
| title_short | Glymphatic system: a self-purification circulation in brain |
| title_sort | glymphatic system a self purification circulation in brain |
| topic | glymphatic system cerebral spinal fluid astrocyte AQP4 brain disease |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1528995/full |
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