SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma
Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of B...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2015/539721 |
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| _version_ | 1850233334920118272 |
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| author | Dongquan Chen Yufeng Li Lizhong Wang Kai Jiao |
| author_facet | Dongquan Chen Yufeng Li Lizhong Wang Kai Jiao |
| author_sort | Dongquan Chen |
| collection | DOAJ |
| description | Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients’ survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients. |
| format | Article |
| id | doaj-art-0331bffbb2b2443db8dda72423f1aa5b |
| institution | OA Journals |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-0331bffbb2b2443db8dda72423f1aa5b2025-08-20T02:02:57ZengWileyInternational Journal of Breast Cancer2090-31702090-31892015-01-01201510.1155/2015/539721539721SEMA6D Expression and Patient Survival in Breast Invasive CarcinomaDongquan Chen0Yufeng Li1Lizhong Wang2Kai Jiao3Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USADivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USAComprehensive Cancer Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USAResearch Division, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USABreast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients’ survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.http://dx.doi.org/10.1155/2015/539721 |
| spellingShingle | Dongquan Chen Yufeng Li Lizhong Wang Kai Jiao SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma International Journal of Breast Cancer |
| title | SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma |
| title_full | SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma |
| title_fullStr | SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma |
| title_full_unstemmed | SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma |
| title_short | SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma |
| title_sort | sema6d expression and patient survival in breast invasive carcinoma |
| url | http://dx.doi.org/10.1155/2015/539721 |
| work_keys_str_mv | AT dongquanchen sema6dexpressionandpatientsurvivalinbreastinvasivecarcinoma AT yufengli sema6dexpressionandpatientsurvivalinbreastinvasivecarcinoma AT lizhongwang sema6dexpressionandpatientsurvivalinbreastinvasivecarcinoma AT kaijiao sema6dexpressionandpatientsurvivalinbreastinvasivecarcinoma |