The impact of creatine supplementation on the development of kidney disease – literature review
Introduction: Creatine, a widely studied dietary supplement, is known for enhancing athletic performance and muscle strength. Concerns persist regarding its impact on kidney health, as it raises serum creatinine levels, potentially confounding renal function assessments. This review examines creati...
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| Format: | Article |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57864 |
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| author | Mateusz Matczak Karol Jasiński Aleksandra Broda Kacper Hoksa Krzysztof Jodłowski Ewa Dubniewicz Paula Majewska Alicja Staszek Wiktoria Łoskot Jan Szwech |
| author_facet | Mateusz Matczak Karol Jasiński Aleksandra Broda Kacper Hoksa Krzysztof Jodłowski Ewa Dubniewicz Paula Majewska Alicja Staszek Wiktoria Łoskot Jan Szwech |
| author_sort | Mateusz Matczak |
| collection | DOAJ |
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Introduction: Creatine, a widely studied dietary supplement, is known for enhancing athletic performance and muscle strength. Concerns persist regarding its impact on kidney health, as it raises serum creatinine levels, potentially confounding renal function assessments. This review examines creatine’s role in sports and clinical contexts, emphasizing safety and kidney health implications.
Aim of the study: To assess the effects of creatine supplementation on kidney function by summarizing evidence from case studies, clinical trials, and long-term research, addressing safety concerns in healthy and at-risk individuals.
State of knowledge: Research supports creatine’s efficacy in improving athletic performance, recovery, and muscle strength, with therapeutic benefits in neurodegenerative diseases, type 2 diabetes, aging, and chronic conditions. Robust trials show no adverse renal effects in healthy individuals, even with long-term or high-dose use. However, case reports highlight potential risks for individuals with pre-existing kidney conditions, especially without monitoring. Elevated serum creatinine levels caused by creatine can mislead eGFR-based renal function tests, warranting cautious interpretation.
Conclusions: When used as recommended, creatine is safe and effective for improving athletic and clinical outcomes in healthy individuals. While no direct renal impairment has been observed, caution is essential for those with kidney conditions. Pre-supplementation renal assessments, individualized dosing, and regular monitoring are advised to minimize risks. Creatine remains a valuable supplement, and further research is needed to confirm its long-term safety across various populations.
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| format | Article |
| id | doaj-art-03304335608e49ca8bd82cbfe9d7a533 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-03304335608e49ca8bd82cbfe9d7a5332025-02-12T08:26:25ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.57864The impact of creatine supplementation on the development of kidney disease – literature reviewMateusz Matczak0https://orcid.org/0009-0000-9701-406XKarol Jasiński1https://orcid.org/0009-0004-6845-5199Aleksandra Broda2https://orcid.org/0009-0004-5179-9411Kacper Hoksa3https://orcid.org/0009-0007-9832-7093Krzysztof Jodłowski4https://orcid.org/0009-0003-9041-2091Ewa Dubniewicz5https://orcid.org/0009-0007-4191-6794Paula Majewska6https://orcid.org/0009-0003-7934-397XAlicja Staszek7https://orcid.org/0009-0007-0323-8697Wiktoria Łoskot8https://orcid.org/0009-0001-5392-4835Jan Szwech9https://orcid.org/0009-0002-9312-8152Hospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzProvincial Hospital of St. Luke in Tarnów, 33-100 Tarnów, ul. Lwowska 178aHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzHospital of the Ministry of Interior and Administration in Lodz, ul. Północna 42, 91–425 LodzCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 LodzCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 LodzCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 LodzUniversity Clinical Hospital No. 2 of the Medical University of Lodz: Łódź, ul. Stefana Żeromskiego 113, 90-549 ŁódźMasovian Specialist Hospital, ul. Jana Aleksandrowicza 5, 26-617 Radom Introduction: Creatine, a widely studied dietary supplement, is known for enhancing athletic performance and muscle strength. Concerns persist regarding its impact on kidney health, as it raises serum creatinine levels, potentially confounding renal function assessments. This review examines creatine’s role in sports and clinical contexts, emphasizing safety and kidney health implications. Aim of the study: To assess the effects of creatine supplementation on kidney function by summarizing evidence from case studies, clinical trials, and long-term research, addressing safety concerns in healthy and at-risk individuals. State of knowledge: Research supports creatine’s efficacy in improving athletic performance, recovery, and muscle strength, with therapeutic benefits in neurodegenerative diseases, type 2 diabetes, aging, and chronic conditions. Robust trials show no adverse renal effects in healthy individuals, even with long-term or high-dose use. However, case reports highlight potential risks for individuals with pre-existing kidney conditions, especially without monitoring. Elevated serum creatinine levels caused by creatine can mislead eGFR-based renal function tests, warranting cautious interpretation. Conclusions: When used as recommended, creatine is safe and effective for improving athletic and clinical outcomes in healthy individuals. While no direct renal impairment has been observed, caution is essential for those with kidney conditions. Pre-supplementation renal assessments, individualized dosing, and regular monitoring are advised to minimize risks. Creatine remains a valuable supplement, and further research is needed to confirm its long-term safety across various populations. https://apcz.umk.pl/QS/article/view/57864creatinesupplementationkidneykidney diseasesport |
| spellingShingle | Mateusz Matczak Karol Jasiński Aleksandra Broda Kacper Hoksa Krzysztof Jodłowski Ewa Dubniewicz Paula Majewska Alicja Staszek Wiktoria Łoskot Jan Szwech The impact of creatine supplementation on the development of kidney disease – literature review Quality in Sport creatine supplementation kidney kidney disease sport |
| title | The impact of creatine supplementation on the development of kidney disease – literature review |
| title_full | The impact of creatine supplementation on the development of kidney disease – literature review |
| title_fullStr | The impact of creatine supplementation on the development of kidney disease – literature review |
| title_full_unstemmed | The impact of creatine supplementation on the development of kidney disease – literature review |
| title_short | The impact of creatine supplementation on the development of kidney disease – literature review |
| title_sort | impact of creatine supplementation on the development of kidney disease literature review |
| topic | creatine supplementation kidney kidney disease sport |
| url | https://apcz.umk.pl/QS/article/view/57864 |
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