Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia
Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/396395 |
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| _version_ | 1832561193668050944 |
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| author | Terrie Flatt Kathleen Neville Karen Lewing Jignesh Dalal |
| author_facet | Terrie Flatt Kathleen Neville Karen Lewing Jignesh Dalal |
| author_sort | Terrie Flatt |
| collection | DOAJ |
| description | Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. Now 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia. |
| format | Article |
| id | doaj-art-03242a7a10064dff865843bf2f220974 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-03242a7a10064dff865843bf2f2209742025-02-03T01:25:38ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/396395396395Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic LeukemiaTerrie Flatt0Kathleen Neville1Karen Lewing2Jignesh Dalal3Division of Hematology/Oncology, Department of Pediatrics, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USADivision of Hematology/Oncology, Department of Pediatrics, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USADivision of Hematology/Oncology, Department of Pediatrics, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USADivision of Hematology/Oncology, Department of Pediatrics, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USAFanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. Now 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia.http://dx.doi.org/10.1155/2012/396395 |
| spellingShingle | Terrie Flatt Kathleen Neville Karen Lewing Jignesh Dalal Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia Case Reports in Hematology |
| title | Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia |
| title_full | Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia |
| title_fullStr | Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia |
| title_short | Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia |
| title_sort | successful treatment of fanconi anemia and t cell acute lymphoblastic leukemia |
| url | http://dx.doi.org/10.1155/2012/396395 |
| work_keys_str_mv | AT terrieflatt successfultreatmentoffanconianemiaandtcellacutelymphoblasticleukemia AT kathleenneville successfultreatmentoffanconianemiaandtcellacutelymphoblasticleukemia AT karenlewing successfultreatmentoffanconianemiaandtcellacutelymphoblasticleukemia AT jigneshdalal successfultreatmentoffanconianemiaandtcellacutelymphoblasticleukemia |